Exam 4 - Lec 60 ADHD Yang

Question 1

T or F: the dopamine transporter is an implicated system in the pathophysiology of ADHD

Answer 1

T

Question 2

possible circuity mechanism of ADHD

Answer 2

medial prefrontal cortex (mPFC) control might not be fully functional

Question 3

what drug class is caffeine in?

Answer 3

methylxanthines

Question 4

the A1 receptor is ____-linked and involves inhibitory modulation of many NTs

Answer 4

Gi/o

Question 5

which is NOT a CNS effect of A1 activation?

a. sedation
b. anxiolysis
c. anticonvulsant activity
d. dec HR

Answer 5

d. dec HR (this is a peripheral effect)

Question 6

A2A receptors are ____-linked

a. Gi
b. Gs
c. Gq

Answer 6

b. Gs

Question 7

A2B receptors are Gs-linked and mostly on ____ cells

Answer 7

glial

Question 8

which of the following is FALSE about A3 adenosine receptors?

a. Gq-linked
b. only activated in states of excessive catabolism
c. antagonized by methylxanthines

Answer 8

c. antagonized by methylxanthines (NOT antagonized by methylxanthines)

Question 9

examples of states of excessive catabolism (3 of them; slide 16)

Answer 9

seizures
hypoglycemia
stroke

Question 10

T or F: methylxanthines dec alertness and inc fatigue

Answer 10

F (inc alertness, dec fatigue)

Question 11

what drug underlined is an indirect-acting sympathomimetic?

Answer 11

cocaine

Question 12

cocaine inhibits which three monoamine transporters?

Answer 12

NE, 5-HT, DA

Question 13

atomoxetine is a _____ inhibitor

Answer 13

NET

Question 14

modafinil is approved for ________ not ADHD

Answer 14

narcolepsy

Question 15

Solriamfetol is used for tx of what two conditions?

Answer 15

OSA, EDS due to narcolepsy

Question 16

solriamfetol is in what drug class?

Answer 16

DNRI (dopamine and NE reuptake inhibitor; they work on DAT and NET)

Question 17

pitolisant is a ____ antagonist/inverse agonist (presynaptic)

Answer 17

H3