Hepatitis Serology Flashcards

1
Q

HBsAg

A

Hepatitis B surface antigen
Marker of viral replication and thus ACTIVE infection

First antibody to appear and triggers production of anti HBS

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2
Q

When does HbsAg appear and disappear by?

A

appears within 6 weeks of infection, disappears by 3 months after

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3
Q

What does HbsAg imply?

A

Acute disease (1-6 months)

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4
Q

What does HbsAg presence for >6 months imply?

A

if HBsAg is present for > 6 months then this implies chronic disease (i.e. Infective)

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5
Q

Anti-Hb

or HbsAB

A

anti-hepatitis B surface antibody

Marker of previously cleared infection / vaccination
(either exposure or immunisation). It is negative in chronic disease

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6
Q

HbeAg

A

HbeAg results from breakdown of core antigen from infected liver cells as is, therefore, a marker of infectivity

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7
Q

HBeAb

A

Natural immunity to hep B

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8
Q

Anti Hbc

A

Anti-HBc implies previous (or current) infection. IgM anti-HBc appears during acute or recent hepatitis B infection and is present for about 6 months. IgG anti-HBc persists

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