23. DISORDERS OF MALABSORPTION. COELIAC DISEASE. CYSTIC FIBROSIS.

Question 1

Specific antibodies found in celiac disease:

Answer 1

antibodies against tissue transglutaminase (Ttg2) and endomysial antibodies (EMA)

Question 2

Celiac’s genetic predisposition:

Answer 2

Genetic predisposition is related to HLA DQ2 and DQ8 of T cells.

Question 3

Diagnosis of celiac disease:

Answer 3

is based on clinical symptoms, positive tTG antibodies, EMA, HLA DQ2 or HLA DQ8 and typical duodenal histology- small bowel biopsy showing various degrees of villous atrophy (short or absent villi), mucosal inflammation, crypt hyperplasia, and increased numbers of intraepithelial lymphocytes.

Question 4

Allergic bronchopulmonary aspergillosis (ABPA):

Answer 4

is a hypersensitivity reaction to Aspergillus in the CF airways. It causes airway inflammation/obstruction and aggravates CF lung disease.