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immunology > extra 2 > Flashcards

extra 2 Flashcards

1
Q

graft bw genetically identical

A

allograft

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2
Q

regular graft
first set reejction
second set

A

revascularization
healing
resolution

revasculariaxtion
cellular infiltration
thrombosis and necrosis

cellular infilatration
thrombosis and necrosis

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3
Q

what tests showed us that T cels mediate graft rejection

A

adoptive transfer experiment

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4
Q

MHC differences found in

A

heterozygous outbred populations

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5
Q

sensitization stage of graft rejection

A

CD4,8+ cells recognize ALLOANTIGEN

proliferate
5% recognize antigenic MHC (ALLORECOGNITION) directly or indirectly

form memory T cells

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6
Q

effector stage of graft rejection

A

mediated by massive infiltration of recipeitn cells

macrophages
neutrophils
ADCC
lytic enzymes
apoptosis
CD4,8+
compliment

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7
Q

hyperacture rejection

A

preexisting antibodies acivate compliment BEFORE REVASCULARIZATION

within 24 hrs

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8
Q

what mediates hyperactute rejection

A

antibodies

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9
Q

what mediates acute rejection

A

t cells

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10
Q

timeline for acute rejection

A

7-10 days

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11
Q

what mediates chronic rejection

A

humoral or cell mediated

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12
Q

acute rejection steps

A

massive infiltration of lymphoxttes and macrophages

-Th activation and effecotr stage steps

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13
Q

what are the viruses in pigs

A

PERVs

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14
Q

how do we remove enzymes that make the sugars in pig cells

A

homologous recombination

prevent the previously acquired immunity

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15
Q

how can we elimininate lymphocytes

A

total lymphoid irradiation

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16
Q

what is total lymphoid irradiation used for

A

bone marrow transplant and graft versu host disease

removes lymphocytes and allows donor stem cell to form its own new imune system

17
Q

what are the generla immune suppresant drugs

A

azathioprine and cyclophosphamide

both w corticosteroids

18
Q

azathiorprine

A

mitotic inhibitor stops b and t cell proliferation

19
Q

cyclophosphamide

A

inserts into DNA helix and disrupts it

20
Q

whats better, azathioprine w cortico or cyclophosphamide w cortico

A

cyclophosphamide

21
Q

what are the two names of teh specific immunosupressive drugs

A

belatracept

OKT3

22
Q

belatracept

A

soluble CTLA4 fusion protein- induces T cell anergy

23
Q

OKT3

A

mAb for CD3- depletes T cells prior to transplant

24
Q
A

immunology (30 decks)

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