Quesmed videos (myelofibrosis)

Question 1

What is myelofibrosis?

Answer 1

A myeloproliferative disorder of unknown cause leading to fibrosis of the bone marrow.

Question 2

What is the most common feature of myelofibrosis?

Answer 2

Pancytopenia - an overall deficiency of all the blood cells (red cells, white cells and platelets)

Question 3

What are common symptoms of myelofibrosis?

Answer 3

Weight loss

Fever

Night sweats

Question 4

Hepatomegaly is more common than splenomegaly in myelofibrosis. True/false?

Answer 4

False

Splenomegaly is more common, hepatomegaly only occurs in around 50% of patients.

Question 5

What is a characteristic feature of myelofibrosis on blood film?

Answer 5

Poikilocytes (tear drop cells)

REMEMBER: “Myelo-cry-brosis”

Question 6

What appears on bone marrow aspiration for myelofibrosis?

Answer 6

Dry tap

Question 7

What are the potential causes of anaemia in the elderly?

Answer 7

Iron deficiency

B12/folate deficiency

Alcohol excess

CKD (chronic kidney disease)

Myelofibrosis

Myeloma

Anaemia of chronic disease

Chronic lymphocytic leukaemia