Bleeding Disprders

Question 1

What is thrombocytopenia

Answer 1

Decrease in platelet number

Question 2

What are thrombocytes

Answer 2

Platelets

Question 3

What is the normal platelet count

Answer 3

150-400 x 10^9/L

Question 4

What causes thrombocytopenia

Answer 4

Failure of marrow production
Shortened lifespan
Dilution
Pooling of platelets

Question 5

What is idiopathic thrombocytopenic purpura (ITP)

Answer 5

Sudden onset of immunological destruction of platelets

Question 6

How is ITP diagnosed

Answer 6

Low platelet count
Platelets often large
Hb and WBC normal

Question 7

What is thrombotic thrombocytopenic purpura (TTP)

Answer 7

Formation of vWF multimeters leading to platelet aggregation

Question 8

What is disseminated intravascular coagulation (DIC)

Answer 8

Wide spread inappropriate intravasular deposition of fibrin with consumption of coagulation factors and platelets

Question 9

What is Bon willebrand disease (VWD)

Answer 9

The most common inherited bleeding disorder

Question 10

How do you diagnose vWF

Answer 10

Prolonged bleeding
Normal platelet number
aPTT prolonged
PT normal
VWF levels low