THERAPEUTICS - paracetamol Flashcards
what is paracetamols chemical name?
acetaminophen
what are the properties of aspirin?
mild-moderate pain relief
anti-pyretic
anti-inflammatory
what are paracetamols effects?
no effects on platelet aggregation
little respiratory effect
little cardiovascular effect
little / no gastric irritation
what are the indications for paracetamol?
first line dental
inflammatory conditions
when NSAIDs are CI
GI, renal, coagulopathies
what forms can paracetamol come in?
tablet
capsule
elixir
suppository
IV prep
where is paracetamol absorbed?
well absorbed GI
what is the half life of paracetamol?
2-4 hours
how is paracetamol eliminated by the body?
renal
what are the contraindications and side effects of paracetamol?
skin reactions
blood dyscrasias (thrombocytopenia, neutropenia, leucopenia)
what are considerations when giving someone paracetamol in relation to it’s elimination process?
renal insufficiency
what is the standard adult dose of paracetamol?
10-15mg every 4-6hours
daily max 4g
what are the principle interactions of paracetamol?
SCRAPPP
St John’s wort
Carbemazepine
Rifampicin
Alcohol
Phenobarbitol
Phenytoin
Primidone
what is the toxic dose of paracetamol?
20-30 tablets
25g is fatal
how do you treat a paracetamol overdose?
activated charcoal
acetylcysteine IV (oral methionine)
what preparations may you find paracetamol in?
panadol
lemsip
calpol
alvedon
sopadol
co-codamol
