ORAL MED - white patches Flashcards

1
Q

what is the aetiology of white sponge nevus?

A

hereditary but may also be sporadic

very rare

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2
Q

what are signs and symptoms of white sponge naevus?

A

asymptomatic
may feel rough

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3
Q

what are the clinical features of white sponge naevus?

A

white/greyish white patches which merge with the surrounding normal mucosa
firmly adherent
no erythema or ulceration
surface is folded, soft and spongy

affects any area of oral mucosa, very variable

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4
Q

other than the oral cavity, where else does white sponge naevus affect?

A

oesophagus
nasal
genital
ano-rectal mucosa
skin, nails, hair

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5
Q

what investigations are performed for white sponge naevus?

A

diagnosis made clinically and with family history
genetic testing for mutation - keratin 4 +/or 13

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6
Q

what is the management of white sponge naevus?

A

explanation of condition - not potentially malignant

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7
Q

what is the aetiology of leukoedema?

A

secondary to low grade mucosal irritation, causing intracellular oedema in superficial layers of epithelium

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8
Q

what are signs and symptoms of leukoedema?

A

asymptomatic

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9
Q

what are clinical features of leukoedema?

A

buccal and labial mucosa filmy white/grey appearance
soft on palpation

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10
Q

what investigations are performed for leukoedema?

A

diagnosis made on clinical grounds

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11
Q

what is management of leukoedema?

A

explanation of condition
advice - potential source of irritation

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12
Q

what is the aetiology of epitheliolysis (oral mucosal peeling)?

A

secondary to mucosal irritation by toothpaste, mouthwashes

sodium lauryl sulphate in toothpaste

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13
Q

what are signs and symptoms of epitheliolysis?

A

asymptomatic

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14
Q

what are the clinical features of epitheliolysis?

A

strands of gelatinous milky white material
removable by wiping
no abnormality to underlying tissue

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15
Q

what investigations are performed for epitheliolysis?

A

diagnosis normally made on clinical grounds

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16
Q

what is the management of epitheliolysis?

A

explanation of condition
avoidance of sodium lauryl sulphate containing products, cease mouthwash use

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17
Q

what is the aetiology of traumatic keratosis?

A

secondary to physical (frictional), chemical, thermal irritation

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18
Q

what are the signs and symptoms of traumatic keratosis?

A

asymptomatic
affected areas may feel rough or ridged to the tongue

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19
Q

what are the clinical features of traumatic keratosis?

A

white plaque not removed by rubbing/ scraping
may have a shaggy surface, appear macerated or be associated with ridging
clinical appearance should match cause

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20
Q

what investigations should be performed for traumatic keratosis?

A

diagnosis made on clinical grounds
biopsy if cause not clear

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21
Q

what is the management of traumatic keratosis?

A

explanation of condition
management/ removal of cause
if lesion does not resolve - biopsy

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22
Q

what causes stomatitis nicotina?

A

smoking related
60% pipe smokers
30% cigarette smokers

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23
Q

is stomatitis nicotina malignant?

A

not potentially malignant

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24
Q

what are clinical features of stomatitis nicotina?

A

generalised white/ greyish white appearance on the hard palate extending onto soft palate

small red dots <1mm represent inflamed openings of minor salivary glands

25
Q

what is the management of stomatitis nicotina?

A

smoking cessation

26
Q

what is the aetiology of oral lichen planus/ lichenoid reaction?

A

unknown is 75% of cases
25% cases due to medication, dental materials

27
Q

what conditions can mimic oral lichen planus?

A

lupus erythematosus
graft vs host disease

28
Q

what are signs of oral lichen planus/ lichenoid reactions?

A

any site affected
tongue, cheek, and gingivae commonly affected
usually bilateral if lichen planus
palatal mucosa rarely affected but may be in lichenoid drug reactions

can get a combination resulting in a mixture of white and red and ulcerated lesions

29
Q

what is the clinical criteria for oral lichen planus?

A

bullous
lesions are not localised exclusively to the sites of smokeless tobacco placement
lesions are not localised exclusively adjacent to and in contact with dental restorations
lesion onset does not correlate witht he start of a medication
lesion onset does not correlate with the se of cinnamon-containing products

30
Q

describe the appearance of reticular lichen planus?

A

lace like pattern
bilateral

31
Q

describe the appearance of papular lichen planus?

A

slightly raised small papules that can fuse together

32
Q

what are the 2 presentations of gingival lichen planus?

A

desquamative gingivitis
reticular/ plaque - white striations in sulus extending on to gingivae

33
Q

describe the appearance of atrophic lichen planus?

A

tongue can lose all papilla

34
Q

list the types of oral lichen planus

A

reticular
papular
gingival
plaque
atrophic
bullous
erosive, atrophic, and reticular - combinations can occur
erosive, atrophic, plaque

35
Q

describe the appearance of erosive (ulcerative), atrophic and reticular lichen planus

A

ulceration surrounded by atrophy surrounded by striations

36
Q

list the range of symptoms that can occur for oral lichen planus/ lichenoid reaction

A

asymptomatic
affected area may feel rough
soreness only on eating - spicy, salty, acidic, rough, hot foods and tooth brushing
soreness presented at all times exacerbated by factors
symptoms tend to wax and wane in severity
stress may be an exacerbating factor

37
Q

what other sites can be affected by lichen planus/ lichenoid reaction?

A

skin
scalp
nails
genital - vulvovaginal gingival lichen planus

38
Q

what investigations are performed for oral lichen planus/ lichenoid reaction?

A

diagnosis made on clinical grounds if presentation is classical
biopsy
swab if suspect super-added candia
blood test if associated disease suspected

39
Q

what is the initial non-pharmacological management in primary care for oral lichen planus?

A

explanation of diagnosis
ask if other site involvement and refer is necessary
advise potentially malignant
counsel - smoking cessation and alcohol
baseline photographs
consider referral to secondary care if concerns regard:
- possible malignancy
- diagnosis
- ability to manage in primary care

40
Q

what presentation of oral lichen planus is more likely to be malignant?

A

tongue involvement
atrophic and erosive pattern

41
Q

what medications are common culprits of lichenoid reactions?

A

antihypertensives - ACE inhibitors, beta blockers, CCBs, thiazide diuretics, loop diuretics
methyldopa

oral hypoglycaemics- tolbutamide, chlorpropamide

NSAIDS - ibuprofen, naproxen, phenylbutazone

42
Q

what restorative materials usually cause lichenoid reactions?

A

amalgam

43
Q

what test can be performed for lichenoid reactions?

A

patch testing

44
Q

what are the risk factors for malignant transformation in lichen planus/ lichenoid reactions?

A

tongue lesions, smoking, alcohol consumption, atrophic-erosive lesions, hepatitis C infection42 and female sex.

45
Q

what mechanism underlies lichenoid reactions to restorative materials?

A

amalgam dental fillings and their interactions with the electrolytes in saliva

46
Q

what is graft vs host disease and why does it cause lichen planus?

A

Graft-versus-host disease (GVHD) occurs due to the presence of immunocompetent T lymphocytes in the graft attacking the immunodeficient recipient tissue due to histocompatibility differences within 100 days, causing tissue damage

47
Q

what other diseases are associated with lichen planus

A

hep C
lupus erythematous

48
Q

how does hairy leukoplakia present?

A

firmly adherent corrugated surface
lateral border of tongue
often super added candida
uni or bilateral

49
Q

what diseases is hairy leukoplakia associated with?

A

EBV (human herpes virus 4)
HIV
immunosuppressed pts
pts using inhaled corticosteroids

50
Q

what tests should be performed for hairy leukoplakia?

A

biopsy
HIV test

51
Q

what is the term for thrush?

A

acute pseudomembranous candidosis

52
Q

what does thrush present as?

A

white patches removed by scaping leaving an erythematous/ bleeding base

53
Q

what are underlying and/or systemic predisposing factors of thrush?

A

dry mouth
steroid inhaler
anaemia
nutritional deficiency
diabetes
immunosuppressed
extremes of age

54
Q

what investigations are performed for thrush?

A

oral rinse - colony forming units (CFU) per ml of rinse (gold standard)
saliva sample - CFU per ml of saliva
imprint culture - CFU per mm2 mucosa
swab - light or profuse growth

sensitivity to antifungals can be carried out

55
Q

when a pt presents with candidosis what do investigations look for?

A

underlying cuases;
- FBC
- serum B12, folate, ferritin
- HbA1c
- TSH

56
Q

how does chronic hyperplastic candidosis present?

A

firmly adherent white plaques
may be inter-mingles erythema and nodularity
commisure/ anterior region of buccal mucosa
bilateral
may also affect tongue

57
Q

what is a significant aetiological factor of chronic hyperplastic candidosis?

A

cigarette smoking

58
Q

is chronic hyperplastic candidosis malignant?

A

no longer classified as potentially malignant