Nutritional and Immune Mediated Skin Dz Flashcards
Vitamin A deficiency causes
Squamous epithelia hyperkeratotic
Secretory epithelia to undergo squamous metaplasia
What is vitamin A deficiency secondary to?
Dietary deficiency, ↓ intestinal absorption or toxicities
Zinc deficiency (parakeratosis)
Addition of excessive calcium to swine rations → ↑ incidence and severity of prarkeratosis
2-4m of age
Gross lesions of zinc deficiency
Excessive growth and keratinization of skin epithelium with formation of horny crust and fissures
Lesions on esophagus and tongue
Microscopic lesions of zinc deficiency
Acanthosis, parakeratosis, keratinization
Autoimmune immune mediated skin dz
Animal generates Abs to counterparts of its own skin
Hypersensitivity (allergic) immune mediated skin dz
Exaggerated responses by the immune system result in tissue damage
Results in Type 1-4 hypersensitivity
Pemphigus
Immune-mediated skin dz
Development of Abs directed against surface Ags of squamous epithelial cells
Gross lesions associated with pemphigus vulgaris
In dogs and cats
Vesicles affecting the mouth, groin and axillae
Microscopic lesions associated with pemphigus vulgaris
Suprabasilar acantholysis
Basal epidermal cells attached to the BM: tombstones
Gross lesions associated with pemphigus foliaceus
Lesions on the nose and spread to periorbital areas
Microscopic lesions associated with pemphigus foliaceus
Acantholytic process @ a superficial level in the epidermis (subcorneal)
Follicular pustules
Lupus erythematosus types (2)
Systemic lupus erythematous affects multiple tissues including skin
Discoid lupus erythematosus localized to the skin
Lupus erythematosus gross lesions
Face, ears, and nailbeds
Ulcerations, alopecia, hypopigmentation
Lupus erythematosus microscopic lesions
Hydropic degeneration of basal cells
Lymphohistiocytic infiltrate @ dermoepidermal junction (lichenoid or interface dermatitis)
Pigmentary incontinence
