Current use of antimicrobials & antibiotics- FINAL

Question 1

Chlorhexidine is a ____ charged molecule that binds to the ____ charged sites on the cells wall; it destabilizes the cell wall and interferes with ____

Answer 1

postive-charged; negatively-charged; osmosis

Question 2

Lower concentrations of chlorhexidine leads to:

Answer 2

increased permeability and leakage

Question 3

Higher concentrations of chlorhexidine leads to:

Answer 3

precipitation of cytoplasmic contents inducing microbial cell death

Question 4

List the 3 mechanisms of chlorhexidine:

Answer 4

1. high substantivity
2. adhere to soft & hard tissues
3. slow release over 12 hours

Question 5

• Bioresorbable polymer with 2.5mg of chlorhexidine
• inserted into pocket of greater than 5 mm
• release takes 7 days
• dissolves on own
• Significant improvement in CAL when used with SRP

Answer 5

periochip

Question 6

• 10% doxycycline hyclate
• delivered sub G with cannula
• controlled release over 21 days
• Significant improvement of CAL the used with SRP

Answer 6

• doxycycline hyclate gel

Question 7

• 1mg minocycline hydrochloride in bioabsorbale microspheres
• bacteriostatic by inhibiting protein syntehsis
• borad spectrum
• significantly reduced red-complex bacteria in smokers
• greater improvement in PD & CAL regardless of smoking status

Answer 7

Microsphere

Question 8

• non reservable monolithic fiber (ethylene vinyl acetate polymer) contains 25% tetracycline powder
• currently unavailable
• slow release over 10 days
• needs removal
• improves PD, BOP, and CAL when combined with SRP within 6 months

Answer 8

tetracycline fiber

Question 9

Diode laser:

Answer 9

soft tissue

Question 10

Laser used in nonsurgical sulcular debridement in period diseasecontrol

Answer 10

NDYAG