16 Flashcards
(128 cards)
1
Q
Presentation - prolonged duration of sore throat with high fever, rigors, dysphagia, and neck pain and swelling along the SCM muscle
A
Lemierre syndrome
2
Q
What is Lemierre syndrome and what causes it?
A
Severe life-threatening infection that affects young immunocompetent patients, usually caused by GN anaerobic bacillus Fusobacterium necrophorum
3
Q
Pathogenesis of Lemierre syndrome?
A
Begins with an oropharyngeal infection (tonsillitis) or as a complication from dental work or mastoiditis -> bacterium invades lateral pharyngeal space through the lymphatic system and affects the neurovascular structures -> internal jugular vein thrombosis and infection -> may send septic thromboemboli to other organs, particularly the lungs
4
Q
GP bacillus that commonly causes food poisoning and gas gangrene
A
C. perfringens
5
Q
Patients with PCOS are at increased risk of developing ___ and should be screened with ___.
A
DM2; oral glucose tolerance test
6
Q
When is BRCA mutation testing indicated?
A
Family history of ovarian cancer at any age
Personal/family history of breast cancer ate age 50 or less in a first-degree relative
7
Q
Presentation - unilateral abdominal mass, +/- abdominal pain/HTN/hematuria, age 2-5
A
Wilms tumor (nephroblastoma)
8
Q
Wilms tumor may be associated with what syndromes?
A
WAGR (Wilms tumor, Aniridia, GU abnormalities, mental Retardation)
Beckwith-Widemann
Denys-Drash
9
Q
First step in work-up for abdominal mass/suspected Wilms tumor?
A
Abdominal U/S -> contrast-enhanced CT or MRI to evaluate extent of Mass + CT chest (pulm mets)
10
Q
Distinguish neuroblastoma from Wilms tumor based on age.
A
NB - <2 y/o
Wilms - 2-5 y/o
11
Q
DDx - hirsutism in women
A
PCOS Idiopathic Non-classic 21-hydroxylase deficiency Androgen-secreting ovarian tumors/ovarian hyperthecosis Cushing syndrome
12
Q
What factors suggest a diagnosis of PCOS with a CC of hirsutism?
A
Oligomenorrhea, obesity, associated with DM, HLD, HTN
13
Q
What factors suggest idiopathic hirsutism with a CC of hirsutism?
A
Normal menses
Normal serum androgens
14
Q
What factors suggest a diagnosis of non-classic 21-hydroxylase deficiency with a CC of hirsutism?
A
Similar to PCOS
Elevated serum 17-hydroxyprogesterone
15
Q
What factors suggest a diagnosis of androgen-secreting ovarian tumors with a CC of hirsutism?
A
More common in post-menopausal women
Rapidly progress + virilization
Very high serum androgens
16
Q
Elevated testosterone + normal DHEAs -> ?
vs.
Elevated DHEAS + normal testosterone?
A
Elevated T/normal DHEAS -> ovarian source (eg, SL cell tumor)
Elevated DHEAS/normal T -> adrenal tumor
17
Q
MR classically results in a ___ murmur heard best at the apex with radiation to the ___.
A
Holosystolic; axilla
18
Q
Common signs of MR?
A
Exertional dyspnea and fatigue, signs of heart failure, AFib
19
Q
___ infection in pregnancy can cause non-immune fetal hydrops (excessive fluid accumulation in the interstitium). List 3 other non-immune causes.
A
Parvovirus B19
Fetal aneuploidy, CV abnormalities, thalassemia
20
Q
MOA leading to hydrops?
A
High-output heart failure from either immune or non-immune etiologies
21
Q
Most common immune etiology of hydrops?
A
Rh(D) alloimmunization
22
Q
List 4 common medications that may potentiate the anticoagulant effects of warfarin (CYP inhibitors), leading to variable dose response, and/or increase the risk of bleeding.
A
Acetaminophen
NSAIDs
Amiodarone
ABX
23
Q
List 7 medications that may decrease the effect of warfarin as CYP450 inducers.
A
- Carbamazepine
- Phenytoin
- Ginsent
- St. John’s wort
- OCs
- Phenobarbital
- Rifampin
24
Q
List the factor 10 a inhibitors.
A
Direct: rivaroxaban and apixaban
Indirect: fondaparinux
25
List the direct thrombin inhibitors.
Argatroban
Bivalrudin
Dabigatran
26
Presentation - diffuse breast erythema, warmth, pain, edema, peau d'orange appearance
Inflammatory breast carcinoma
27
Presentation - unilateral bloody nipple discharge, no other symptoms or skin changes
Intraductal papilloma
28
Patients with new-onset AFib should have what lab test completed to look for an underlying cause?
TSH/Free T4 levels - occult hyperthyroidism
29
High-frequency hearing loss is associated with aging and certain ___ syndromes.
Congenital long QT
30
Suspect what 4 conditions when a patient presents with hypokalemia, alkalosis, and normotension? Distinguish them.
1. Surreptitious vomiting - low urine Cl
2. Diuretic abuse
3. Bartter syndrome
4. Gitelman's syndrome
All others have high urine Cl
31
Septic arthritis is usually caused by ___. Therefore, empiric treatment with ___ is generally adequate. However, a minority of patients have continued symptoms despite a few days of this treatment, which usually indicates infection with ___. These patients require the addition of ___.
GP aerobic bacteria (especially S. aureus)
Vancomycin
GN bacterium
Ceftriaxone (good choice, as it has GP, GN, and some anaerobic coverage)
32
Why is doxycycline not often used to broaden antimicrobial coverage for severe infections when other ABX choices are available?
It is bacteriostatic (rather than cidal)
33
A ___ presents within the first few months of life as isolated hyperpigmented patches with an increased density of hair follicles.
Congenital melanocytic nevus
34
Describe the appearance of cafe-au-lait spots and 2 associated syndromes.
FLAT hyperpigmented patches
McCune-Albright
NF
35
DDx - bloody diarrhea?
1. E. coli O157:H7
2. Shigella
3. Campylobacter
36
Key features of bloody diarrhea due to E. coli O157:H7 + treatment?
Associated with undercooked beef; can be complicated by HUS
Supportive care only
37
Key features of bloody diarrhea due to Shigella?
Associated with contaminated food or water; often implicated in outbreaks (eg, daycare)
Less commonly complicated by HUS
Supportive care + ABX (azithro, ceftriaxone, ciprofloxacin are options)
38
Key features of bloody diarrhea due to Campylobacter?
Associated with raw or undercooked meat
Can be complicated by GBS
Supportive only
39
Why is E. Coli O157:H7 infection treated with supportive care only?
The risk of HUS increases in patients who receive ABX or antimotility agents
40
Rx severe or high-risk cases of Salmonella gastroenteritis in children?
TMP-SMX
41
What are the main substrates of 4 gluconeogenesis?
Alanine
Glutamine
Lactate
Glycerol 3-phosphate
42
Alanine is converted to ___ during gluconeogenesis.
Pyruvate
43
Glutamine and other glucogenic amino acids enter gluconeogenesis at which step?
Citric acid cycle
44
The liver maintains glucose levels in the blood via glycogenolysis and gluconeogenesis. During fasting states, glycogen reserves drop dramatically in the first 12 hours, by which time gluconeogenesis represents the sole source of glucose production. The main substrates for gluconeogenesis are gluconeogenic amino acids (from ___), lactate (from ___), and G3P (from ___). Alanine is the major gluconeogenic amino acid in the liver and is converted into pyruvate by alanine aminotransferase.
Breakdown of muscle protein; anaerobic glycolysis; triacylglycerol in adipose
45
Presentation - microcephaly, wide anterior fontanelle, cleft lip and palate, distal phalange hypoplasia, cardiac defects
Fetal hydantoin syndrome (exposure to antiepiletpics like phenytoin and carabmazepine)
46
Features of chronic hyperthyroid myopathy?
Painless proximal muscle weakness in the setting of clinical features of hyperthyroidism, muscle atrophy
47
Matching is frequently used in case-control studies because it is an efficient method to control ___. What should the matching variables be?
Confounding; the potential confounders
48
Empiric therapy for UTI?
Third-generation cephalosporin (cefixime, ceftriaxone)
49
Rx otitis externa?
Topical antipseudomonal treatment (ciprofloxacin, other FQ) +/- topical glucocorticoid
50
What is the most common cause of death in patients with ESRD?
CV disease
Traditional risk factors - HTN, DM, dyslipidemia, LVH, advanced age, low physical activity
ESRD-specific risk factors: anemia of CKD, vascular calcifications (increased Ph, Ca2+)
Oxidative stress related to uremia and dialysis
51
For patients who present soon after a single, potentially toxic ingestion (>7.5 g) of acetaminophen, what is the first step in management? If they are asymptomatic?
Gastric decontamination with activated charcoal (if within 4 hours of ingestion) and measurement of acetaminophen levels, use nomogram to guide N-acetylcysteine
Doesn't matter - patients can be asymptomatic during the first 24 hours
52
Empiric ABX Rx of native-valve endocarditis should be geared toward what bugs? What is the best choice?
MRSA, streptococci, enterococci; Vancomycin
53
5 classes of medications that commonly cause urinary incontinence?
1. Alpha-adrenergic antagonists (relax urethra)
2. Anticholinergics, opiates, CCBs (urinary retention/overflow)
3. Diuretics (excess urine production)
54
Defense mechanism - transferring feelings to a less threatening object/person
Displacement
55
Defense mechanism - expressing unacceptable feelings through impulsive physical actions
Acting out
56
Defense mechanism - attributing one's own feelings to someone else
Projection
57
Defense mechanism - transforming unacceptable feelings into their extreme opposite
Reaction formation
58
Patients with hepatic encephalopathy on diuretics can develop low intravascular volume despite having total volume overload, leading to a ___ with associated ___. Management?
Metabolic alkalosis; hypokalemia
Volume resuscitation and repletion of hypokalemia in addition to serum ammonia-lowering medications (eg, lactulose)
59
When is TIPS indicated?
When a patient has ascites that does not respond to medical therapy or has ongoing active or recurrent variceal bleeding even after appropriate treatment with upper endoscopy
60
Presentation - high fevers, severe polyarthrlagias, fever, malaise, rash, LAD, lymphopenia, thrombocytopenia, recent travel to tropical/sutropical parts of Central/South America, Africa, and Asia
Chikungunya fever
61
Transmission of Chikungunya fever?
Aedes mosquito
62
Expected murmur in IVDU + bacterial endocarditis?
Tricuspid regurgitation (R-sided heart valve involvement) -> systolic murmur that increases on inspiration
63
Cause of Wernicke encephalopathy?
Thiamine deficiency (followed by glucose infusion)
64
PVCs are often present in patients with recent or prior MI; routine therapy for suppression of PVCs is not indicated in asymptomatic patients. Patients with frequent symptomatic PVCs should be treated with what medications?
Beta blockers or CCBs
If maxed out doses - consider amiodraone
65
EKG features of PVCs?
QRS >0.12 seconds
Bizarre morphology not resembling any conduction abnormality
T wave in the opposite direction of QRS axis
Compensatory pause
66
All patients with carotid artery stenosis should receive what treatment?
Medical therapy with antiplatelet agents and statins
67
Findings suggestive of renal artery stenosis in the setting of renal allograft?
```
Within 2 years of transplant
Persistently elevated BP
DECLINE IN RENAL FUNCTION WITH THE ADDITION OF ACEIs
Lateralizing abdominal bruit
Recurrent flash pulmonary edema
```
68
Although the majority of affected infants with NEC are premature or have very low birth weight, term infants with what conditions are also at risk?
Reduced mesenteric oxygen delivery from cyanotic congenital heart disease and/or hypotension
69
Peak airway pressure is the sum of what two factors?
Airway resistance and plateau pressure
70
What is plateau pressure?
Sum of the elastic pressure and positive end-expiratory pressure (PEEP)
(When pulmonary airflow and thus resistive pressure are both 0)
71
What is calculated by performing the end-inspiratory hold maneuver?
Plateau pressure
72
What is calculated with the end-expiratory hold maneuver?
PEEP
73
What is peak airway pressure?
Maximum pressure measured as the TV is being delivered
74
What is elastic pressure?
Product of the lung's elastance and the volume of gas delivered
Can be calculated as TV/compliance -> decreased compliance = stiffer lungs and higher elastic pressure
75
Increased peak pressure + normal plateau pressure DDx
Bronchospasm
Mucus plug
Biting endotracheal tube
76
Increased peak pressure + increased plateau pressure DDx
```
Pneumothorax
Pulmonary edema
Pneumonia
Atelectasis
R mainstem intubation
```
77
Dx and Rx intussusception?
U/S-guided air (or saline) contrast enema
+/- surgery to remove the lead point
78
Arteriosclerotic lesions of afferent and efferent renal arterioles and glomerular capillary tufts - caused by what process?
HTN
79
Increased extracellular matrix, BM thickening, mesangial expansion, and fibrosis of the kidneys - caused by what process?
DM nephropathy
80
Primigravida patient with hematochezia, abdominal pain, and tenesmus (aka fecal urgency followed by straining and inability to defecate)
UC
81
Maternal and fetal complications associated with maternal UC?
Pregnancy is a high-risk period -> worsening UC disease (severe hematochezia, anemia, toxic megacolon)
Fetal risks - preterm delivery, SGA
82
Management of UC in pregnancy?
Ideally, remission before conception
Medication management - meds are considered safe throughout pregnancy and breastfeeding (except for sulfasalazine during breastfeeding - lack of safety data)
83
The primary anti-ischemic and anti-anginal effects of nitrates are due to what?
SYSTEMIC vasodilation (rather than coronary vasodilation) -> lowers preload and LV end-diastolic volume -> reduces wall stress and myocardial oxygen demand
84
What is the most significant risk factor for spontaneous preterm delivery?
Hx of spontaneous preterm delivery in a prior preganncy
85
Management of patients with a history of spontaneous preterm delivery?
IM Progesterone supplementation in T2/3 and serial cervical length measurements (TVUS) during T2
Cerclage placement if needed
86
Distinguish between the 2 major types of painful genital ulcers.
1. HSV - small vesicles, erythematous base, mild LAD
2. H. ducreyi (chancroid) - large, deep ulcers with gray/yellow exudate, soft friable base, severe LAD that may suppurate
87
Features of Lambert-Eaton syndrome?
Proximal muscle weakness
Autonomic dysfunction (eg, dry mouth, erectile dysfunction)
CN involvement (eg, ptosis)
DIMINISHED OR ABSENT DTRs
88
Features of dermatomyositis?
Symmetrical proximal muscle weakness, erythematous rash on dorsum of fingers (Gottron's sign) and/or upper eyelids (heliotrope eruption)
89
Screening lab findings of muscular dystrophies?
Elevated serum creatine phosphokinase and aldolase levels
90
Muscle biopsy findings in muscular dystrophies?
Fibrosis and fatty infiltration, absent dystrophin on staining
91
Gold standard diagnosis of Duchenne muscular dystrophy?
Genetic testing - deletion of the dystrophin gene on Xp21 (X-linked recessive condition)
92
Atopic keratoconjunctivitis is a severe form of ocular allergy - how can it be distinguished from allergic conjunctivitis?
More severe symptoms, prolonged course, potential visual impairment if corneal involvement, and thickening of the eyelids and surrounding skin
93
What is endophthalmitis and how does it present?
Invasive infection of the globe due to disruption of the external surface of the eye (eg, trauma) - purulent haziness of the ocular contents, may have a layering-out of pus in the anterior chamber (hypopyon)
94
What is viral keratitis and how does it present?
Infection of the cornea related to HSV or VZV; corneal vesicles, opacification, and/or dendritic ulcers
95
Patients with COPD who have resting arterial oxygen tension (PaO2) of ___ or pulse oxygen saturation (SaO2) ___ are candidates for long-term home oxygen treatment.
55 or less mmHg; 88% or less
If signs of right heart failure or Hct >55%, start if PaO2 59 or less/SaO2 89% or less
96
Goal SaO2 for patients with COPD on supplemental O2?
>90% during sleep, normal walking, and rest
97
For a normal distribution, what % of all observations lie within 1, 2, and 3 SD from the mean?
68%; 95%; 99.7%
98
First question to ask in treating a patient with a proximal (eg, popliteal, femoral) lower extremity DVT?
PE with hemodynamic instability or massive proximal (eg, extensive iliofemoral) DVT with severe swelling or limb-threatening ischemia?
If yes -> consider thrombolytics
If no -> consider anticoagulation
99
When should an IVC be placed in the setting of proximal lower extremity DVT?
Contraindications to anticoagulation
Failure of anticoagulation
Recurrence of DVT
100
Options when a patient needs thrombolytics in the setting of a proximal lower extremity DVT but there are contraindications (or thrombolytics fail)?
Mechanical thrombectomy
Iliac stenting
Surgical thrombectomy
101
Presentation - progressive dyspnea, decreased exercise tolerance, AF with RVR, and LV systolic dysfunction
Tachycardia-mediated cardiomyopathy (many tachyarrhythmias can lead to this)
102
Rx of tachycardia-mediated cardiomyopathy?
Aggressive rate control or restoration of normal sinus rhythm (due to potential reversibility and normalization of LV function)
103
Level of block in Mobitz type I vs. II
I: usually AV node
II: below level of AV node (eg, bundle of HIS)
104
EKG findings in Mobitz type I vs. II
I: progressive prolonged PR interval leads to a non-conducted P wave ("group beating")
II: PR interval remains constant with intermittent non-conducted P waves
105
QRS complex in Mobitz type I vs. II
I: narrow
II: narrow or wide
106
Effect of exercise or atropine in Mobitz type I vs. II
I: improves type I AV block
II: worsens type II AV block
107
Effect of vagal maneuvers (carotid sinus massage) in Mobitz type I vs. II
I: worsens type I AV block
II: paradoxically improves type II AV block
108
Risk of complete heart block in Mobitz type I vs. II
I: low risk
II: higher risk
109
Rx Mobitz type I?
Observation if asymptomatic and correction of reversible causes
110
___ can cause low back pain associated with claudication of the hip muscles and possibly impotence.
Iliac artery thrombosis
111
___ during patient handoffs are a large contributor to medical errors and adverse patient outcomes.
Communication failures between physicians
112
Medical errors resulting from communication failures between medical providers are most effectively addressed with what intervention?
Systematic signout process that includes checklists to improve efficacy and accuracy
113
Features of granulomatosis with polyangiitis (upper respiratory, lower respiratory, renal, skin)
UR: sinusitis/otitis, saddle-nose deformity
LR: lung nodules/cavitation, tracheal narrowing with ulceration
Renal: rapidly progressive GN (extremely common)
Skin: livedo reticularis, non-healing ulcers
Anemia of chronic disease
114
Dx GPA?
ANCA (PR3 in 70%, MPO in 20%)
| Bx: skin (leukocytoclastic vasculiti), kidney (pacui-immune GN), lung (granulomatous vasculitis)
115
Management of GPA?
Steroids and immunomodulators (eg, MTX, cyclophosphamide, rituximab)
116
Gold standard method of diagnosing CIN?
Colposcopy
117
___ causes acute, diffuse, non-inflammatory hair loss and is often triggered by a stressful event. Presentation?
Telogen effluvium; widespread thinning of hair, but the scalp and hair shafts appear normal (self-limited, resolves within a year)
118
Circumscribed patches of hair loss, hair shafts show narrowing close to the surface and may be broken off
Alopecia areata (autoimmune disorder)
119
Uneven hair loss in a characteristic pattern (M - frontotemporal hairline and vertex, F - vertex and sides, preservation of hairline)
Androgenetic alopecia
120
Fragility of hair with breaking of strands, fractured strands with splitting of fibers
Trichorrhexis nodosa
121
Who gets a statin?
1. Clinically significant ASCVD (ACS, stable angina, arterial revascularization, stroke, TIA, PAD); high-intensity unless age >75 (moderate)
2. LDL 190+
3. Age 40-75 with DM; high-intensity unless 10-year ASCVD risk <7.5% (moderate)
4. Estimated 10-year ASCVD risk 7.5% or higher (moderate to high)
122
LP findings in GBS (Guillain-Barre syndrome)?
Elevated protein level with NORMAL CELL COUNT, normal RBCs and glucose levels
123
Most common predisposing factor for orbital cellulitis?
Bacterial sinusitis
124
Amantadine is a drug that may be used in the Rx of ___.
Parkinson disease
125
Drugs used in the treatment of Alzheimer dementia?
Donepezil (cholinesterase inhibitor)
| Memantine (NMDA receptor antagonist)
126
3 methods to control confounding in the design stage?
Matching
Restriction
Randomization
127
2 methods to control confounding in the analysis stage?
Stratified analysis
| Statistical modeling
128
Secondary malignancy is common in patients with Hodgkin lymphoma treated with chemo and radiation. What are the most common secondary solid tumor malignancies?
Lung, breast, thyroid, bone, GI
