208- benign and malignant uterus Flashcards
1
Q
when do leiomyomas first begin to develop
A
when you reach repro age (they are estrogen dependent). Start to go away after menopause
2
Q
what do you see in histology of leiomyoma? What factor is increased? What other abnormalities
A
increase extra cellular matrix relative to myometrium.
THF beta
40% have chromosomal abnormalities
3
Q
what is the pathophys of leiomyoma
A
neoplastic transformation of single cell which undergoes monoclonal expansion
4
Q
relation of progesterone to leiomyoma
A
increased so it provides therapeutic target
