225- prostate histo Flashcards
1
Q
histology of BPH
A
2 cell layers thick in the glands (as opposed to CA which has no basal layer)
2
Q
what is the main type of prostate cancer? what drives it? what race? precursor lesions?
A
adenocarcinoma. Androgen dependent. African Americans.
Prostatic Intraepithelial neoplasia (PIN): retains basal layer (cancer loses basal layer and invades)
3
Q
histo changes in cancer
A
presence of acinar nucleoli, smaller glands, absence of basal cells, greater N:C ratio
4
Q
staining of high grade PIN vs cancer
A
HGPIN has more racemase and less p63?
5
Q
what is gleason grading based on
A
based on architecture pattern, ignores cytologic features. You add the two (1-5) scores from each pattern and get a sum score from 2-10
