17B Assignment Flashcards
Cdt1 is activated by ____________.
APC/C induced destruction of geminin
accumulation of geminin
destruction of Cdc6
binding of geminin
APC/C induced destruction of gemini
During metaphase………………
nuclear envelope breaks down.
nuclear envelope re-assembles.
chromosome attach to spindle.
microtubules for the first time.
chromosomes align at the spindle equator.
chromosomes align at the spindle equator.
Condensins ________________.
compact chromosomes when phosphorylated by M-Cdk
are made of the exact same protein subunits as cohesins
are involved in keeping the sister chromatids apart
bind to DNA in G1 phase
compact chromosomes when phosphorylated by M-Cdk
Cdc20–APC and Cdh1–APC complexes are similar because……………………
They are both active throughout interphase.
They both inhibit M-Cdk activity.
They are both inactivated soon after anaphase.
They are both activated suddenly at the onset of mitosis.
They both inhibit M-Cdk activity.
ORC is phosphorylated in which phase?
S phase
G1 phase
G2 Phase
Mitosis
S phase
DNA helicase deposition on DNA at the replication origins occurs mainly in which phase of cell cycle?
G1 phase
S phase
G2 phase
mitosis
G1 phase
At the beginning of S phase in a cycling cell, which of these events are likely to occur?
Activation of Cdh1–APC/C
Activation of Cdc20
Activation of geminin
Activation of M-Cdk
Activation of geminin
In the metaphase to anaphase transition, activation of which of these factors is important?
Cdc20-APC/C complex
Cdh1- APC/C complex
Helicase
S-Cdk
Cdc20-APC/C complex
Which of these complexes keep M-cyclin levels low in G1 phase of cell cycle?
Cdc20–APC/C
Skp2–SCF
p27-Cdk
Cdh1–APC/C
Cdh1–APC/C
S-cdk ensures that replication happens only once per cell cycle- how?
It promotes the assembly of a prereplicative complex.
It phosphorylates the Cdc6 protein, marking it for destruction.
It phosphorylates and inactivates DNA helicases
It blocks the rise of Cdc6 concentrations early in G1.
It phosphorylates the Cdc6 protein, marking it for destruction.
If a cell in G1 phase and another cell in G0 phase are induced to pass the restriction point by the addition of a signaling molecule, but the signal is then immediately removed, what is likely to occur?
Both cells will replicate their DNA.
Only the G1 cell will replicate its DNA.
Only the G0 cell will replicate its DNA.
Neither of the cells will replicate their DNA
Both cells will replicate their DNA.
Disassembly of nuclear envelope marks which phase of mitosis?
Metaphase
Anaphase
Prometaphase
Prophase
Prometaphase
