Flashcards in 18. Characteristic of tumours Deck (72)
What does the stroma provide?
- mechanical support
- intercellular signalling
What is a desmoplastic reaction?
Fibrous stroma formation due to induction of connective tissue fibroblast proliferation by growth factors from the tumour cells
What does the stroma contain? (in a desmoplastic reaction)
- cancer-associated fibroblasts
- myofibroblasts (see puckering of skin)
- blood vessels (blood to tumour)
What are the clinical complications of tumours dependent on?
- cell of origin
In what general classifications can effects of tumours be?
- due to metastases
What are some LOCAL complications of tumours?
Compression is a local complication of tumours. Describe this
Displacement of adjacent tissue
- benign eg. pituitary adenomas obliterate adjacent functioning pituitary tissue leading to hypopituitarism
Destruction is a local complication of tumours. Describe this
Rapidly fatal is vital structures are invaded e.g. artery
Mucosal surfaces - ulceration eg. GI - anaemia
Describe tumour type-specific METABOLIC complications of tumours?
- well differentiated endocrine tumours can retain functional properties
- number of cells exceeds normal organ
- eg. thyrotoxicosis in thyroid adenoma
- if inappropriate (paraneoplastic) eg. ACTH/ADH in small cells lung cancer
Give some non-specific METABOLIC complications of tumours
- warburg effect
- venous thrombosis
What is cachexia?
Profound weight-loss despite apparently adequate nutrition
Tumour-derived humoral effects that interfere with protein metabolism