19. Adrenergic & Angiotensin Block in CHF Flashcards Preview

CVPR Exam I > 19. Adrenergic & Angiotensin Block in CHF > Flashcards

Flashcards in 19. Adrenergic & Angiotensin Block in CHF Deck (21):
1

What is the difference in SE btw an ACE-inhibitor and an ARB?

all the same except with ARBs, no cough and less angioedema

2

What are the ACE inhibitors' side effects?

1. cough (dry, nonproductive) 2. hyperkalemia 3. angioedema 4. renal problems 5. neutropenia 6. hypotension

3

ACE is an enzyme produced in the ____.

lungs

4

How is the RAAS stimulated?

1. hypovolemia 2. low NaCL

5

Hydralazine is a _____.

vasodilator

5

ACE inhibitors end in -_____.

opril

6

Name the 2 vasodilators that are most commonly used.

1. hydralazine 2. isosorbide

7

What is stage B HFrEF?

heart structure problem w/o symptoms

8

ACE inhibitors block both ____ and ____.

angiotensin conversion to angiotensin-II AND bradykinin conversion to its inactive fragments

8

What does angiotensin II do?

1. vasoconstriction 2. increased sympathetic output 3. increased aldosterone production and Na+ reab 4. increased ADH release 5. increased thirst

10

The ARBs end in -_____.

sartan

11

What is stage C HFrEF?

structural disease w/ symptoms

12

ARBs mainly have an effect on the ____ receptor.

AT1

14

What is your target creatinine clearance level?

< 30

15

What does digoxin do?

increases CO and SV

16

Angiotensinogen is a zymogen produced in the ____.

liver

17

High bradykinin causes?

a cough, remodeling of the LV, and vasodilates

18

If your pt is stage C HFrEF and is black, add ____ in addition to the beta blocker and ACEI/ARB.

hydralazine and isosorbide

19

Bradykininogen is a zymogen produced in the ____.

liver

20

What is stage D HFrEF?

refractory - hospitalized pts

21

Why do African Americans need a vasodilator, too?

1. they get HFrEF at an earlier age 2. their HFrEF is more advanced 3. they have a higher rate of mortality and hospitalizations 4. they have more TGF-beta (increased fibrosis) 5. they have increased vasothelin 6. sometimes they're NO synthetase deficient 7. the RAAS is decreased