2-3 McNaughton Flashcards Preview

MODA List 1 > 2-3 McNaughton > Flashcards

Flashcards in 2-3 McNaughton Deck (29)
Loading flashcards...
1
Q

Alemtuzumab

A

Fully humanised monoclonal antibody to control inflammation
Targets CD52 - B and T cell destruction
Binds B cells and mark for destruction by cell based immunity
Used in B cell Chronic Lymphocytic Leukemia
Auto immune - target T cell markers
Acquired immunity is reset

2
Q

Aspirin

A

Non-selective COX inhibitor
NSAID - irreversible inactivation
Donate acetyl group to serine near COX active site
Effective in low doses at preventing platelet aggregation
Removes pro-coagulatory effect of TXA2 secreted by platelets
Can cause salicylate poisoning, Reyes syndrome

3
Q

Azathioprine

A

Inhibit immune cell proliferation
Inhibit synthesis of guanine, and DNA synthesis
Limited to B and T cells, as others have salvage pathways

4
Q

Celecoxib

A

COX-2 selective NSAID
Too bulky to enter COX-1 channel
Do not inhibit prostanoid synthesis

5
Q

Cimetidine

A

H2 selective antagonist
Treat gastric ulceration
Reduces gastric acid secretion

6
Q

Clarithromycin

A

Antibiotic to treat Helicobacter Pylori

7
Q

Cyclosporin

A

Calcineurin inhibitors, inhibit T cell proliferation
Inhibit early activation
Inhibit secretion of IL2

8
Q

Dexamethasone

A

Long acting >48hrs clinically used corticosteroid

9
Q

Dimenhydrinate

A

H1 antagonist
Limited use as antihistamine
CNS side effects - used to treat motion sickness

10
Q

Ibuprofen

A

Reversible NSAID
Non-selective
Compete with arachidonic acid for binding COX enzymes

11
Q

Infliximab

A

Monoclonal antibody to control inflammation
Targets (bind and sequesters) TNFa
Rheumatoid arthritis, Crohns disease

12
Q

Ipratropium

A

Muscarinic antagonist

Asthma and respiratory diseases

13
Q

Loratidine

A

3rd generation antihistamine (H1 antagonists)

Few CNS affects and no affect on heart

14
Q

Methotrexate

A

Disease modifying anti-rheumatoid drugs
Inhibits folate biosynthesis, thymidine availability and DNA replication
Antiproliferative
used in cancer chemotherapy

15
Q

Metoclopramide

A

D2 antagonist

anti-emetic

16
Q

Mycophenolate

A

Autoimmune/prevent organ rejection
Inhibit immune cell proliferation
inhibit synthesis of guanosine and therefore inhibit DNA synthesis
The effect is limited to B, T cell proliferation
because other cells possess an alternative salvage pathway for guanosine synthesis

17
Q

Omalizumab

A

Monoclonal targeting IgE

IgE mediated asthma

18
Q

Omeprazole

A

Proton pump inhibitor

Reduce gastric acid secretion

19
Q

Ondansetron

A

5-HT3 antagonist

anti-emetic

20
Q

Paracetamol

A

Non-selective COX inhibitor
May act on COX-3 - CNS specific cyclo-oxygenase
Little anti-inflammatory effect

21
Q

Prednisolone

A
Short acting (<24hrs) corticosteroid
Prednisone is precursor
22
Q

Ranitidine

A

H2 selective antagonist
Treat gastric ulceration
Reduces gastric acid secretion

23
Q

Scopolamine

A

Muscarinic antagonist

Anti-emetic

24
Q

Sirolimus

A

Autoimmune disease and prevent organ rejection
mTOR inhibitor (mammalian target of rapamycin) inhibitor
Blocks late activation of T and B cells

25
Q

Sulfasalazine

A

Interfere with lymphocyte behaviour

Treat rheumatoid arthritis

26
Q

Sumatriptan

A

5-HT1D agonist
Suppress migraine
NSAID (triptan)
Terminate an attack

27
Q

Tacrolimus

A

Autoimmune/prevent organ rejection
Calcineurin inhibitor - prevent T cell proliferation
Inhibit secretion of IL2

28
Q

Zafirlukast

A

Maintenance treatment of asthma
specific cysteinyl leukotriene receptor antagonists
D4 and E4 receptor antagonist

29
Q

Zileuton

A

Maintenance treatment of asthma
Inhibitor of 5-lipoxygenase
Inhibit synthesis of leukotrienes