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Pharmo Test Two Old Test Review > 2020 Exam 3 > Flashcards

2020 Exam 3 Flashcards

1
Q
  1. Which drug prevents conversion from angiotensinogen  angiotensin I
A

a. Aliskiren

Aliskerin is a direct renin inhibitor. We know that renin convert angiotensinogen into angiotensin I. Therefore aliskerin prevents renin from converting angiotensinogen into angiotensin I

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2
Q
  1. What is a side effect of ACE inhibitors due to bradykinin (occurs 10% of the time)
A

a. Cough

ACE inhibitors stop both ACE (in vasoconstriction) and KININASE II (in vasodialation).

Its affect on Kininase II causes build up of bradykinn and results in a cough and angioedema.

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3
Q
  1. Which of the following drugs does not have an adverse drug reaction of hyperkalemia
A

a. Minoxidil

This is because minoxidil opens KATP channels and turns off voltage gated Ca channels

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4
Q
  1. What receptor results in vasoconstriction, bronchoconstriction, and increased aldosterone secretion when endothelin-1 binds to it
A

a. Eta

Typically we know endothelins as vasocontrictiors, along with angiotensin II

ETa- is the receptor type that always “constrictions”

ETb- is the receptor that does vasodialtion, and inhibition of platelet aggregation

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5
Q
  1. What is the effect of nitric oxide
A

a. Increase in cGMP

compare that to prostaglandin which increases CAMP and decreased CA++

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6
Q
  1. What activates adenylyl cyclase resulting in an increase in cAMP
A

a. Prostacyclin

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7
Q
  1. What results in hair growth
A

a. Minoxidil

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8
Q
  1. Sildenafil is a part of what classification
A

a. PDE-5 inhibitors

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9
Q
  1. Pulmonary arterial HTN is considered what group by WHO?
A

Class I

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10
Q
  1. What drug decreases formation of IP3 through blocking ETa receptors
A

a. Bosentan

this is an endothelin 1 recptor antagonist: we know endothelin

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11
Q
  1. What drug can be taken orally, inhaled, IV, or subcutaneously
A

a. Treprostinil

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12
Q
  1. What is bad cholesterol
A

a. LDL

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13
Q
  1. What is good cholesterol
A

HDL

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14
Q
  1. A 50yo lady smokes tobacco, has high blood pressure, and diabetes mellitus. How many risk factors for atherosclerotic disease does she have
A

a. 3

the risk factors include: 
men great or = to 45 
women older or = to 55 
DM
Fat
hyperlipidemia
HTN
smoking
lazy
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15
Q
  1. What -statin ha the least amount of drug-drug interaction
A

a. Pravastatin

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16
Q
  1. Which drug has pleiotrophic effects such as plaque stabilization and reduced inflammation
A

a. -statin

17
Q
  1. Which of the following drugs is pregnancy a contraindication
A

a. -statin

18
Q
  1. What is a rare reaction of Simvastatin
A

a. Memory loss

19
Q
  1. (it was a drug with -fib- in it, so it is a fibrate) has what mechanism of action
A

a. Agonist of PPARa nuclear receptor increasing lipoprotein lipase levels

20
Q
  1. Bile acid binding agents do what?
A

a. Increase triglycerides

21
Q
  1. Ezetimibe has what mechanism of action
A

a. Blocks the NPC1L1 transport protein

this transport protien is locateds in the enterocyte

22
Q
  1. Which drug has an adverse drug reaction of flushing
A

a. Niacin

23
Q
  1. What does PCSK-9 inhibitors mainly do
A

a. Decrease LDL

24
Q
  1. What is the term for stopping bleeding from an injured blood vessel
A

a. Hemostasis

25
Q
  1. What are the 3 Virchow’s Triad?
A

a. Stasis, vessel wall injury, hypercoagulability

26
Q
  1. What is the vitamin K-dependent clotting factor
A

a. There were 2 right answers (II, VII)

the vitamin K dependent are 2, 7, 9, 10

27
Q
  1. What stage does thrombin come into play
A

a. Activation

28
Q
  1. What is the mechanism of action for TPA

TPA= Tissue Plasminogen Activator

A

a. Converting plasminogen to plasmin

29
Q
  1. Which of the following is an anti-fibrinolytic medication
A

a. Tranexamic acid

the two Antifibrinolytic meds are:

  • aminocaproic acid
  • tranedxamic acid
30
Q
  1. Which of the following drugs has an adverse drug reaction of a “purple toe”
A

a. Warfarin

31
Q
  1. Which of the following drugs has a mechanism of action regarding the inhibition of VKORC1
A

a. Warfarin

32
Q
  1. What is the coagulation parameter for warfarin
A

a. INR

33
Q
  1. What drug results in the activation of antithrombin III which inhibits factor Xa (NOT thrombin)
A

a. Tinzaparin
i. ^ low molecular weight heparin

compare this to the function of whole herparin: Which affects both Xa and thrombin.

34
Q
  1. Which drug inhibits the conversion of prothrombin to thrombin
A

a. Edoxaban

this is a factor Xa inhibitor. This means whether the intrisic 12, 11, 9, 10 OR the extrinsic which ic TF+7a to Xa to Thrombin. both are stopped at the level before prothromin.

35
Q
  1. Which of the following is a P2Y12 inhibitor
A

a. Clopidogrel

36
Q
  1. What drug is associated with shortness of breath
A

a. Ezetimibe

I couldn’t find this in the slide.

37
Q
  1. Which drug has GI problems
A

a. Colestipol

Pharmo Test Two Old Test Review (8 decks)

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