Receptors Flashcards
a1 receptor
Sympathetic, Gq
Increases vascular smooth muscle contraction, intestinal and sphincter muscle contration, pupillary dilator muscle contraction.
What is the difference between nicotinic and muscarinic receptors?
Nicotinic: ACh receptors, ligand gated Na+/K+ channels, found in autonomic ganglia (first order) and somatic neuromuscular junction/skeletal muscle.
Muscarinic: ACh receptors, GPCRs, parasympathetic and sweat gland 2nd order neurons.
a2 receptor
Sympathetic, Gi
Decreases sympathetic outflow, decreases insulin release and lipolysis, increases platelet aggregation
b1 receptor
Sympathetic, Gs
Increases HR and contractility, increases renin, increases lipolysis
b2 receptor
Sympathetic Gs
Vasodilation, bronchodilation, increases HR and contractility, increases lipolysis and insulin release, decreases uterine tone, ciliary muscle relaxation, increase aqueous humor production
M1 receptor
Parasympathetic Gq
CNS and enteric NS
M2 receptor
Parasympathetic, Gi
Decreases HR and atrial contractility
M3 receptor
Parasympathetic, Gq
Exocrine gland secretions, peristalsis, bladder contraction, bronchoconstriction, pupillary sphincter muscle and ciliary muscle contraction
D1 receptor
Dopamine receptor, Gs
Relaxes renal vascular smooth muscle
D2 receptor
Dopamine receptor, Gi
Modulates neurotransmitter release
H1 receptor
Histamine receptor, Gq
Nasal and bronchial mucus production, increased vascular permiability, bronchiole constriction, pruritis, pain
H2 receptor
Histamine receptor, Gs
Gastric acid secretion
V1 receptor
Vasopressin receptor, Gq
Vascular smooth muscle contraction
V2 receptor
Vasopressin receptor, Gs
Found in kidneys, increases water permeability and readsorption
Gq receptors and mechanism
a1, M1, M3, H1, V1 (HAVMM)
Phospholipase C, IP3 and DAG, PKC and increased Ca –> smooth muscle contraction
