2.15 Pharmacology of Stroke Medications Flashcards Preview

NMSK B Test 1 > 2.15 Pharmacology of Stroke Medications > Flashcards

Flashcards in 2.15 Pharmacology of Stroke Medications Deck (14):
1

What is MOA of warfarin?

Warfarin: Inhibits liver production of vitamin K dependent clotting factors: II, VII, IX, X

2

What is the MOA of Dabigatran?

direct thrombin inhibitor

3

What is the MOA of Rivaroxaban and Apixaban?

Factor Xa inhibitors

4

What are fibrinolytic drugs?

-Alteplase
-Reteplase
-Urokinase
-Tenecteplase
-(historical) Streptokinase

5

What is the MOA of Fibrinolytics?

a

6

What is the only agent class approved for stroke treatment?

Alteplase (r-tPA): Only agent in class approved for stroke treatment; stroke dosing- IV bolus then 60 min infusion

7

What are uses of Fibrinolytics?

-Catheter occlusions,
-DVT
-MI
Peripheral arterial occlusions
-Pulmonary embolism
-Stroke

8

What major adverse effect of fibrinolytic therapy?

Intracranial hemorrhage

9

What is the MOA of Aspirin?

-Inhibit Aggregation
-Block cyclo-oxygenase (COX-1)

10

What is the MOA of Clopidogrel, prasugrel, ticagrelor, and ticlopidine?

- Inhibit Aggregation
-Block ADP receptor (P2Y12)

11

What is the MOA of Abciximab, tirofiban, and eptifibitide?

-Inhibit aggregation
-Block IIb-IIIa receptor

12

What is the MOA of Vorapaxar?

-Inhibit aggregation
-Block thrombin receptor (PAR-1)

13

What is the MOA of dipyridamole?

- Inhibit aggregation
-Increase adenosine levels

14

What is the checklist used for?

Cognitive Aid