Flashcards in 2.15 Pharmacology of Stroke Medications Deck (14)
What is MOA of warfarin?
Warfarin: Inhibits liver production of vitamin K dependent clotting factors: II, VII, IX, X
What is the MOA of Dabigatran?
direct thrombin inhibitor
What is the MOA of Rivaroxaban and Apixaban?
Factor Xa inhibitors
What are fibrinolytic drugs?
What is the MOA of Fibrinolytics?
What is the only agent class approved for stroke treatment?
Alteplase (r-tPA): Only agent in class approved for stroke treatment; stroke dosing- IV bolus then 60 min infusion
What are uses of Fibrinolytics?
Peripheral arterial occlusions
What major adverse effect of fibrinolytic therapy?
What is the MOA of Aspirin?
-Block cyclo-oxygenase (COX-1)
What is the MOA of Clopidogrel, prasugrel, ticagrelor, and ticlopidine?
- Inhibit Aggregation
-Block ADP receptor (P2Y12)
What is the MOA of Abciximab, tirofiban, and eptifibitide?
-Block IIb-IIIa receptor
What is the MOA of Vorapaxar?
-Block thrombin receptor (PAR-1)
What is the MOA of dipyridamole?
- Inhibit aggregation
-Increase adenosine levels