Anti- TB drugs

Question 1

primary drugs for TB

Answer 1

isoniazid, rifampin, ethambutol, pyrazinamide

Question 2

Isoniazid MOA

Answer 2

inhibits mycolic acid synthesis (inhibit cell wall synthesis), uses bacteria to be converted to active drug (resistance caused by deletion of a gene katG)

Question 3

Isoniazid SE

Answer 3

hepatitis (worse as age increases), peripheral neuritis (Tx with B6), Sideroblastic anemia (Tx with B6), SLE possible very rare

Question 4

Rifampin MOA

Answer 4

blocks DNA dep RNA poly thus is inhibiting transcription

Question 5

Rifampin SE

Answer 5

hepatitis, P450 inducer, red-orange metabolites in urine

Question 6

Ethambutol MOA

Answer 6

inhbiits arabinogalactan (cell wall synthesis)

Question 7

Ethambutol SE

Answer 7

dose dependent reticulobulbar neuritis leading to red/green color blindness

Question 8

pyrazinimide SE

Answer 8

hepatitis, hyperuricemia

Question 9

streptomycin MOA

Answer 9

IV aminoglycoside

Question 10

Streptomycin SE

Answer 10

deafness, vestibular dysfxn, nephrotox, NMJ blockade