Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Step One R&M > Leukocyte extravasation and wound healing > Flashcards

Leukocyte extravasation and wound healing Flashcards

1
Q

Secreted by platelets and macrophages

A

PDGF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

What is the function of TGFß in wound repair?

A

Stimulates angiogenesis and fibrosis as well as cell cycle arrest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is the function of FGF?

A

Stimulates all aspects of angiogenesis during wound repair

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Stimulates fibrosis during wound repair

A

TGFß

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Biopsy of a wound one week after injury would reveal a predominance of which type of cell?

A

Fibroblast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Functions of PDGF

A
  1. Vascular remodeling and SMC migration
  2. Fibroblast growth
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the function of MMPs during wound healing?

A

Tissue remodeling

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Mediates vascular remodeling

A

PDGF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Stimulates all aspects of angiogenesis during wound repair

A

FGF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Stimulates cell growth by acting via tyrosine kinases

A

EGF

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What factors mediate migration?

A

C5a, LTB4, kallikrein, platelet-activating factor, IL-8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Name a drug that affects leukocyte extravasation

A

Glucocorticoids (increase PMN count)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What type of collagen is present in a wound from 2 days-1 week

A

Type III (granulation tissue)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What type of collagen replaces granulation tissue after about a week of wound repair?

A

Type I (skin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Mediates cell cycle arrest

A

TGFß

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Name a disease that affects leukocyte extravasation

A

Leukocyte adhesion defect = defect in LFA1 integrin (CD11/18) on leukocytes so PMNs can’t tightly bind to endothelium

15
Q

Tissue remodeling during wound repair

A

MMPs

17
Q

What adhesion molecules mediate margination and rolling?

A

E-selectin –> Sialyl-LewisX

P-selectin –> Sialyl-LewisX

GlyCAM-1, CD-34 –> L-selectin

18
Q

What is the function of EGF?

A

Stimulates cell growth via tyrosine kinases

20
Q

Mediates fibroblast growth

A

PDGF

21
Q

What secretes PDGF?

A

Platelets and macrophages

22
Q

What factors mediate tight binding?

A

ICAM-1 (CD54) –> CD11/18 integrins

VCAM-1 (CD106) –> VLA-4 integrin

23
Q

What factors mediate diapedesis?

A

PECAM-1 (CD31) –> PECAM-1 (CD31)

24
Q

Where does leukocytes extravasation take place?

A

Postcapillary venules

25
Q

What are the steps in leukocyte extravasation?

A

Margination/rolling

Tight binding

Diapedesis

Migration

Step One R&M (38 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions