Forty Two Flashcards
What are the 3 types of cerebral cortex? What makes up 90% of the cortex?
The term cortex means the outer covering of the cerebrum. It is highly folded because of
the confined space of the skull during fetal development. The cortex consists of gryi
(convolutions) and sulci (grooves). There are three types of cortex: neo-, paleo-, and
archicortex. The neocortex appears latest in evolution and constitutes about 90% of the
total cerebral cortex. The paleocortex is restricted to the base of the telencephalon and is
associated with the olfactory system, while the archicortex comprises the hippocampal
formation. Since the paleocortex is closely associated with olfaction and the archicortex
is a part of the limbic system, both are considered with those systems.
What are the two main neuronal cell types in the cortex? What do they look like? What is their function? Where do they synapse?
The young adult cortex contains billions of neurons consisting of five types of cells. The
two main neuronal cell types are the pyramidal and granule cells. The pyramidal cells
are comprised of a pyramid-shaped cell body which gives off a large apical dendrite
directed toward the surface of the cortex and several large basal dendrites that pass
horizontally from the base of the cell. The axon proceeds from the base of the cell and in
most cases leaves the cortex to reach other cortical areas or subcortical nuclei. The
pyramidal cells are, therefore, the chief cortical efferent or output neurons.
The granule or stellate cells are the main interneurons of the cortex and greatly
outnumber the pyramidal cells. These small cells give off numerous short dendrites in all
directions and a short axon that arborizes on the other neurons in the vicinity. Granule
cells occur in great numbers in all cortical areas and are especially numerous in the
sensory and association areas.
How is the cortex arranged anatomically? Name the six layers.
The neurons of the neocortex are arranged in six horizontal layers. Most superficial is
the cell-poor molecular layer and deepest is the multiform layer. In between are
alternating external and internal granular (layers 2 and 4) and pyramidal (layers 3 and 5)
layers.
How is the cortex arranged functionally?
Although the neurons of the cortex are arranged in six layers oriented parallel to the
surface, the functional units of cortical activity are organized in groups of neurons
oriented perpendicular to the surface. These vertically oriented functional units are
called cortical columns and appear to average about 300 microns in diameter and to
contain thousands of neurons that are interconnected in the vertical direction. Each
column forms a working unit with a very specific function.
What are 4 types of neurons or connection sin the cerebral cortex? Generally, where does each originate and where does it synapse? From which layer does it originate and which layers receive synapses?
The neurons of the cerebral cortex have: 1) intracortical, 2) associational, 3) commissural
and 4) subcortical connections. Intracortical connections are quite short and occur
chiefly through the axons of horizontal cells in layer I and horizontally coursing
collaterals from the axons of the pyramidal neurons in other layers. The association
neurons are pyramidal cells in layer III which give rise to axons that enter the subcortical
white matter and pass to other cortical areas in the same hemisphere. Commissural
neurons are pyramidal cells in layer III whose axons enter the white matter and pass via
the corpus callosum or anterior commissure to cortical areas usually homologous, in the
opposite hemisphere. Subcortical connections occur via projection fibers that arise from
pyramidal neurons chiefly in layer V, although some in layer VI also contribute to this
group. Layer V gives rise to most of the corticofugal projection fibers, i.e., spinal,
nuclear, pontine, rubral, striate, reticular, etc., while layer VI gives rise to the
corticothalamic projection fibers.
As far as the distributions of incoming fibers are concerned, the association and
commissural fibers end chiefly in layers II and III. The specific thalamocortical
projections terminate in layer IV. In general, therefore, layer IV is considered to be
chiefly responsible for receiving input, layers V and in a more limited sense VI as
chiefly responsible for output, and the supragranular layers I, II and III, chiefly
involved in associational activities.
What are association fibers? What are two kinds and what are they like? Give some examples.
Connections from gyrus to gyrus and from lobe to lobe in the same hemisphere are
made via the association fibers. The short association fibers (arcuate fibers or loops)
connect adjacent gyri, while the long association fibers form bundles that connect more
distant gyri. The main long association bundles are the superior longitudinal fasciculus
and its temporal component, the arcuate fasciculus, the uncinate fasciculus, the
inferior longitudinal fasciculus and the cingulum.
What are commisural fibers? What are two examples? What are they like and where are they located?
Connections between neocortical areas of the two hemispheres occur via the
commissural fibers. Two main groups exist: the corpus callosum and the anterior
commissure. The anterior commissure has several components, the most important of
which interconnects the middle and inferior temporal gyri.
The corpus callosum reaches is greatest development in man. It contains more than 300
million fibers which for the most part interconnect homologous cortical areas.
What are projection fibers? What are the two different kinds?
Projection fibers connect the cerebral cortex with subcortical nuclei and are classified as
corticofugal if they carry impulses away from the cortex, or corticopetal if they carry
them toward the cortex. The corticofugal projection fibers are distributed to nuclei at all
levels of the brainstem and spinal cord and most have been described with the motor
system. The corticopetal projection fibers arise chiefly in the thalamus and can be
distributed to specific or to widespread cortical areas. In most cases the connections
between the thalamic nuclei and the cerebral cortex are reciprocal.
How is the cerebral cortex divided anatomically? Functionally? What are primary, secondary, and association areas?
Anatomically, the cerebral cortex is described according to lobes (frontal, parietal,
temporal, occipital, etc.), which are subdivided into gyri. Functionally, the cortex is
described according to the numerical areas that were originally demarcated by Brodmann,
not on the basis of function but on cytoarchitecture. In addition, the cortex can also be
subdivided into primary, secondary and association areas. Primary areas have specific
functions that include voluntary movement, somatosensation, vision and audition.
Adjacent to the primary areas are secondary areas that have similar but more complex functions. Association areas correlate information from widespread sources and are related to higher mental functions. Most of the human cerebral cortex consists of association areas, allowing us to put thoughts together.
What are 3 general disorders that might result from damage to association areas? Describe them.
Damage to association areas may result in: 1) agnosia, the inability to interpret sensory
stimuli, such as sounds or images; 2) apraxia, the inability to carry out a voluntary
movement in the absence of paralysis, sensory loss and ataxia; and 3) aphasia, the
inability to understand or communicate speech, writing or signs.
Where is the primary visual cortex? How is it broken up? What information does it receive/project? When it is stimulated by visual input, what are the two places it projects? Where do these areas project to? What is the function of these last areas of visual info?
The occipital cortex contains the primary visual and visual association areas. The primary visual cortex (Brodmann’s area 17), also called the striate area, receives the optic radiation from the thalamus and is located in the gyri forming the walls of the calcarine fissure. The inferior part of the cuneus forms the upper wall of the very deep calcarine fissure and here is represented the lower half of the contralateral field of vision. The upper half of the contralateral visual field is projected to the lingual gyrus which forms the lower wall of the calcarine fissure.
When stimulated by visual input the striate cortex relays information to the parastriate
(association) visual cortex. These areas consist of area 18, the parastriate cortex, and area
19, the peristriate cortex. These extrastriate areas interpret input from the primary
visual cortex and project to the temporal and parietal association cortices so that the
meaning of a visual image may be interpreted and remembered. Evidence suggests that
the temporal association cortex analyzes the form and color of the visual scene while
those in the parietal cortex analyze the spatial aspects of vision, such as the analysis of
motion and positional relationships between objects in the visual scene. Connections
from the extrastriate areas to the temporal and parietal associations areas are respectively
called the “what?” and “where?” pathways of visual processing.
What do unilateral lesions of the primary visual cortex result in? Lesions of the extrastriate cortex? Lesions of where pathway? Lesions of the what pathway?
Unilateral lesions of the primary visual cortex result in contralateral homonymous
hemianopsia with or without macular sparing.
Lesions of the extrastriate cortex, specifically those that involve the dorsal spatial
pathway (“where?”) that projects to the parietal lobe can result in the inability to
appreciate the motion of objects. Lesions involving the ventral object recognition
pathway (“what?”) that project to the temporal lobe can result in the inability to see the
world in color, referred to as cerebral achromatopsia.
What functions does the temporal cortex contain? Where is the primary auditory cortex located? Where Wernickes area located? What is its function? What is the homologous area on the non-dominant hemisphere involved with?
The temporal cortex forms almost a fourth of the entire cortex and contains the auditory
area as well as areas associated with emotions and higher mental functions such as
memory and speech. The auditory cortex is situated in the transverse temporal gyri of Heschl which is buried in the wall of the lateral fissure. The primary area, #41, is chiefly in the anterior gyrus although it may extend slightly into the adjacent part of the posterior gyrus.
The posterior part of area 22 in the superior temporal gyrus, usually the left (dominant
hemisphere), comprises the sensory or receptive speech area, called Wernicke’s. This
area contains the mechanisms for the comprehension and formulation of language. The
homologous area on the non-dominant hemisphere is important in the hearing of sounds,
rhythm and music.
What do the inferior and medial portions of the temporal lobe comprise? What are they involved with?
The inferior and medial portions of the temporal lobe comprise a major component of the
limbic lobe. These temporal structures include the hippocampus and parahippocampal
gyrus and are involved in establishing new declarative memories. The sensation of
olfaction is mediated through the limbic system as well as is emotional and affective
behavior. Olfactory fibers terminate in the uncus, the most medial edge of the anterior
part of the parahippocampal gyrus.
What do the middle and inferior temporal gyri comprise? What is their function? Give examples.
The middle and inferior temporal gyri comprise temporal association cortex. These
areas store auditory and visual information. For example, temporal association cortex on
the dominant hemisphere stores information that links speech sounds with their symbolic
significance while the non-dominant hemisphere stores visually based information.