Cardiology Biochem

Question 1

Function of apoAI

Answer 1

Activates LCAT; structural HDL component

Question 2

Function of apoB48

Answer 2

Assembly/secretion of chlyomicrons from small intestine

Question 3

Function of apoB100

Answer 3

VLDL assembly/secretion (liver)

VLDL, IDL, LDL structural protein

LDL receptor ligand for extrahepatic cells

Question 4

Function of apoCII

Answer 4

Cofactor activator of LPL

Question 5

Function of apoE

Answer 5

VLDL and chlyomicron remnant uptake by the liver

Question 6

Function of apo (a)

Answer 6

Unknown; linked by disulfide bond to apoB100

Question 7

Cause of familial hyperchylomicronemia (type I)

Answer 7

LDP or apo-CII deficiency

Question 8

Lipoprotein fractions seen in familial hyperchylomicronemia (type I)

Answer 8

Increased chylomicrons

Increased TGs

Question 9

Cause of familial hypercholesterolemia (type IIa)

Answer 9

Defect in LDL receptor

Question 10

Lipoprotein fractions seen in familial hypercholesterolemia (type IIa)

Answer 10

Increased LDL

Question 11

Cause of familial mixed hyperlipidemia (type IIb)

Answer 11

Defect in internalization of LDL receptor

Question 12

Lipoprotein fractions seen in familial mixed hyperlipidemia (type IIb)

Answer 12

Increased LDL, VLDL, and TGs

Question 13

Cause of familial dysbetalipoproteinemia (type III)

Answer 13

Defect in apo-E

Question 14

Lipoprotein fractions seen in familial dysbetalipoproteinemia (type III)

Answer 14

Increased IDL (beta VLDL)
Increased chlyomicron remnants

Question 15

Cause of familial hypertriglyceridemia (type IV)

Answer 15

Multiple factors

Question 16

Lipoprotein fractions seen in familial hypertriglyceridemia (type IV)

Answer 16

Increased VLDL and TG

Question 17

Cause of familial mixed hypertriglyceridemia (type V)

Answer 17

LPL deficiency plus increased VLDL production

Question 18

Lipoprotein fractions seen in familial mixed hypertriglyceridemia (type V)

Answer 18

Increased VLDL, chlyomicrons, and TGs