Antifungal Drugs Flashcards

1
Q

Amphotericin B

A

Polyene

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2
Q

Nystatin

A

Polyene

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3
Q

Terbinafine

A

Allyamine

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4
Q

Clotrimazole

A

Azole - Imidazole

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5
Q

Miconazole

A

Azole - Imidazole

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6
Q

Ketoconazole

A

Azole - Imidazole

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7
Q

Fluconazole

A

Azole - Triazole

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8
Q

Itraconazole

A

Azole - Triazole

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9
Q

Variconazole

A

Azole - Triazole

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10
Q

Posaconazole

A

Azole - Triazole

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11
Q

Capsofungin

A

Echinocandin

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12
Q

Micafungin

A

Echinocandin

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13
Q

Anidulafungin

A

Echinocandin

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14
Q

5-Flourocytosine action?

A

Taken into cell by fungal specific permease, deaminated to 5-flourouracil which inhibits thymidylate

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15
Q

Griseofulvin action?

A

Inhibition of fungal mitosis

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16
Q

Echinocandins action?

A

Inhibition of beta-1,3 glucansynthase, severely abnormal cell wall.

17
Q

Azoles action?

A

Inhibit ergosterol synthesis

18
Q

Allyanines action?

A

Inhibit ergosterol synthesis by inhibiting squalene epoxidase

19
Q

Polyenes action?

A

Pore formation in ergosterol