25 - DNA Viruses Part 2 (Stapleton)

Question 1

HPV causes what

Answer 1

cell division-hyperplasia

Question 2

cytopathic effect of papilloma virus

Answer 2

koilocytosis-large swollen cells with distorted nuclei

Question 3

HPV proteins causing cancer

Answer 3

E6-inhibit p53

E7-inhibit retinoblastoma protein

Question 4

high risk papilloma virus

Answer 4

causes cancer
highly active E6 and E7
cervical, anal, oropharyngeal cancer
leading killer of 20-29 year olds

Question 5

low risk papilloma virus

Answer 5

benign, warts
poorly active E6 and E7
cutaneous, genital warts

Question 6

papilloma virus transmission

Answer 6

personal contact
sexual
enter site of trauma

Question 7

what serotype for high risk hpv

Answer 7

16 and 18

Question 8

hpv treatment/prevention

Answer 8

no antiviral treatment

virus like particle vaccine for ages 9-26

Question 9

polyomavirus characteristics

Answer 9

small, naked, circular dsDNA

Question 10

types of polyomavirus

Answer 10

JC virus

BK virus

Question 11

polyomavirus spread

Answer 11

respiratory transmission

latent in kidneys, CNS, bone marrow

Question 12

BK virus causes

Answer 12

urinary tract disease

Question 13

JC virus casuses

Answer 13

progressive multifocal leukoencephalopathy

Question 14

adenovirus characteristics

Answer 14

naked
icosahedral
linear dsDNA

Question 15

life cycle of adenovirus

Answer 15

fiber protein interacts with CAR receptor
nuclear replication
replicates vDNA using own DDDP
egress by cell destruction

Question 16

infection from adenovirus

Answer 16

infection of mucosal epithelial cells

site depends on virus type and fiber protein

Question 17

adenovirus spread

Answer 17

fecal oral

Question 18

adenovirus symptoms

Answer 18

URI
keratoconjuntivits
pharyngitis
pharyngoconjunctivitgs
laryngitis
tracheobronchitis
bronchiolitis
infantile diarrhea

Question 19

adenovirus treatment

Answer 19

no antiviral
no vaccines
handwashing

Question 20

parvovirus characteristics

Answer 20

smallest DNA virus
naked
icosahedral
ssDNA
replicate in nucleus

Question 21

what is the receptor for parvovirus

Answer 21

RBC P antigen

infects RBC precursors

Question 22

clinically significant parvovirus

Answer 22

B19

Question 23

primary and secondary infection of parvovirus

Answer 23

cytopathic, kills reticulocytes

non infectious, rash, arthritis

Question 24

parvovirus symptoms

Answer 24

fifths disease-slapped cheek rash
arthritis in adults
aplastic anemia (sickle cell crisis)
congenital infection (hydrops fetalis, fetal loss, fetal anemia)

Question 25

parvovirus treatment

Answer 25

no antiviral or vaccine

Question 26

hep b antigens

Answer 26

envelope protein/surface antigen - HBsAg core antigen HBcAg e antigen HBeAg (released)

Question 27

function of core antigen

Answer 27

carries polymerase with virus RDDP

Question 28

hep b life cycle

Answer 28

``` HBsAg binds receptor capsid migrates through NPC release DNA into nucleus gene expression in nucleus mRNA transported to cytoplasm egress into membrane with HBsAg ```

Question 29

gRNA

Answer 29

used as pregenome packaged in virion with RDDP- makes DNA copy of gRNA

Question 30

acute hep b

Answer 30

more likely to clear more severe with age IgM anti HBc and HBsAg

Question 31

chronic hep b

Answer 31

common with infected babies cirrhosis, end stage liver disease, hepatocellular carcinoma No HBsAb

Question 32

antibody to HBsAg

Answer 32

is protective!!! | induced by vaccine

Question 33

hep b treatment

Answer 33

``` interferon a, nucleoside reverse transcriptase inhibitors HBsAg vaccine (will have anti HBs antibodies) ```

Question 34

hep d

Answer 34

defective, requires HBV | enveloped, negative circular RNA

Question 35

disease from hep d

Answer 35

cannot occur without hep b | treat or prevent hep b

Question 36

hep b and d coinfection

Answer 36

acquired together | fulminant hepatitis

Question 37

hep b and d superinfection

Answer 37

hdv superimposed on chronic hbv | chronic hepatitis and cirrhosis

Question 38

hep with fecal oral

Answer 38

a and e

Question 39

hep with blood

Answer 39

b, d, c

Question 40

a virus family

Answer 40

picornavirus

Question 41

b virus family

Answer 41

hepadna

Question 42

c virus family

Answer 42

flavivirus

Question 43

d virus family

Answer 43

subviral

Question 44

e virus family

Answer 44

calici

Question 45

acute jaundice

Answer 45

all but c

Question 46

chronic hepatitis

Answer 46

all but a and e

Question 47

liver cancer risk

Answer 47

b and c

Question 48

TSE characteristics

Answer 48

``` slowly progressive lethal no treatment infrctious difficult to destroy ```

Question 49

how are TSE created

Answer 49

misfolded PrP (PrPsc=prion) misfold and aggregate kill neurons and lead to disease

Question 50

noninfectious TSE

Answer 50

Familial CJD | sporadic CJD

Question 51

infectious TSE

Answer 51

kuru (cannibalism) iatrogenic (growth hormone, grafts, infected instruments) BSE-mad cow disease