Adrenoreceptor Blockers Flashcards

0
Q

Irreversible Alpha nonselective blocker (forms covalent bond with alpha receptors) (A1>A2)
Drug for pheochromocytoma
SE: orthostatic hypotension, reflex tachycardia

A

Phenoxybenzamine

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1
Q

Nonselective alpha blockers

A

Phenoxybenzamine

Phentolamine

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2
Q

Reversible alpha nonselective blocker (A1>A2)
Drug for rebound hypertension in Clonidine, pre surgical Pheochromocytoma, antidote for alpha1 agonist overdose
SE: Orthostatic hypotension, reflex tachycardia

A

Phentolamine

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3
Q

Alpha1 selective blocker
Drug for BPH
SE: first dose orthostatic hypotension, less chance for refelx tachycardia

A

Prazosin
(Doxazosin, Terazosin, Tamsulosin, Silodusin)
Tamsulosin is most selective for prostatic smooth muscle
Take at night to avoid orthostatic hypotension

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4
Q

Advantage of alpha1 selectivity

A

Reflex tachycardia is less common and less severe

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5
Q

Drug Class of Isoproterenol

A

Non Selective Beta AGONIST

I SOrry, kala ko Beta Blocker ka

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6
Q

Non selective beta blocker
Drug for HPN, Hyperthyroidism, angina prophylaxis
SE: Bronchospasm, erectile dysfunction
Masks initial symptoms of hypoglycemia (tachycardia, tremor, anxiety) in diabetics

A

Propranolol

Pindolol, Timolol, Labetalol, Carvedilol, Nadolol

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7
Q

Drugs with combined alpha and beta blockade

May be used for hypertension in Pheochromocytoma

A

Carvedilol

Labetalol

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8
Q

Side Effect of Beta blockers on DIabetics

A

Can mask premonitory symptoms of hypoglycemia (i.e. Tachycardia, tremor, anxiety)
Impaired hepatic mobilization of glucose

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9
Q

Beta agonists that are less likely to cause bronchospasm
(with intrinsic sympathomimetic activity)
Advantage in pxs with asthma

A

Pindolol
Acebutolol

ISA PA!

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10
Q

Side effects of beta blockers when used topically in the eye

A

Decreases protective reflexes

Increases risk for corneal ulceration

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11
Q

Beta Blockers with Absent Local Anesthetic activity

A

Timolol
Betaxolol

Treat Bulag

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12
Q

Beta blocker with longest half life

A

Nadolol

NAsa DOLO

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13
Q

Beta1 selective blocker
Drugs for HPN, Heart failure, SVT
SE: less likely to cause bronchospasm, erectile dysfunction
Masks initial symptoms of hypoglycemia (tachycardia, tremor, anxiety) in diabetics

A

Atenolol

Betaxolol, Esmolol (SVT), Acebutolol, Metoprolol

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14
Q

Beta blocker with the shortest half-life

A

Esmolol

ESMOL = small = shortest half life

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