NSAIDs, Acetaminophen And Drugs For Gout Flashcards

0
Q

Aspirin dose <300mg/d is for?

A

Low: For platelet aggregation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
1
Q

Antiplatelet drug
Contraindicated in pxs with Gout because it prevents uric acid excretion
Nonselective IRREVERSIBLE COX1/2 inhibitor
Drug for prevention of ARTERIAL thrombosis and for inflammatory disorders
Uncoupler of Oxidative Phosphorylation

A

Aspirin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Aspirin dose 300-2400mg/d is for?

A

Intermediate: Antipyretic and analgesic effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Aspirin dose (2400-4000mg/d) is for?

A

High: Anti-inflammatory effects

Follows Zero Order Elimination (constant amount)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Toxic and Lethal dose of ASA

A

Toxic: 150mg/kg
Lethal: 500mg/kg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Tx for ASA Overdose (Weak acid)

A

Alkalinize Urine with HCO3
Supportive mgmt
Activated charcoal/gastric lavage

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q
Non-selective REVERSIBLE COX1/2 inhibitor
Inhibits Prostaglandin synthesis
Drug for analgesia
SE: GI bleeding (less than ASA)
Long term use reduces risk for Colon CA

Drug, Class

A

Ibuprofen, NSAID nonselective

Marami pang iba

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Non-selective REVERSIBLE COX1/2 inhibitor
Inhibits Prostaglandin synthesis
Drug for POST-SURGICAL analgesia
SE: high risk for GI toxicity and nephrotoxicity
Only IV NSAID

Drug

A

Ketorolac, NSAID nonselective

Restrict use to 72 hours only

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Non-selective REVERSIBLE COX1/2 inhibitor
Inhibits Prostaglandin synthesis
Drug for closure of PDA
SE: serious hematologic reactions

Drug, Class

A

Indomethacin, NSAID nonselective

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Selective COX2 inhibitor, inhibits prostaglandin synthesis
Drug for analgesia, anti-inflammatory
SE: reduced risk for GI bleeding

Drug

A

Celecoxib

Etoricoxib, Parecoxib, Rofecoxib, Valdecoxib

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

COX3 inhibitor, weak COX1 and COX2 inhibitor
Drug for analgesia, antipyretic
SE: hepatotoxicity (inc with alcohol overdose)
Preferred antipyretic in children, does not cause Reye Syndrome

Drug

A

Paracetamol

Acetaminophen, Phenacetin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Antidote for Paracetamol toxicity

A

N-acetylcysteine (sulfhydryl donor)

May do supportive management with gastric decontamination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Identify the Stage of Paracetamol Overdose:

Nausea/vomiting

A

Stage I: up to 24 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Identify the Stage of Paracetamol Overdose:

Hepatotoxicity

A

Stage II: 24-72 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Identify the Stage of Paracetamol Overdose:

ATN, HAGMA

A

Stage III: 72-96 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Identify the Stage of Paracetamol Overdose:

Recovery

A

Stage IV: 4 days to 2 weeks

16
Q

Paracetamol:
Toxic Dose:________
Lethal Dose:________

A

Toxic: 150mg/kg (same as ASA)
Lethal: 15g

17
Q

Inhibits AICAR transformylase
DMARD of choice for RA, chemotherapy
SE: mucosal ulcers, pseudolymphomatous reaction

Drug

A

Methotrexate

18
Q

Rescue agent for MTX toxicity

A

Leucovorin (Folinic acid)

19
Q

Binds to TNF-alpha to prevent binding
DMARD for Crohn’s disease
SE: bacterial infections, reactivation of latent TB, lymphoma
Synergistic with MTX

Drug

A

Infliximab

Adalimumab, Etanercept

20
Q

Forms 6-thioguanine
DMARD for RA
SE: bone marrow suppression, increased incidence of lymphoma
Cannot give with Allopurinol

Drug

A

Azarhioprine

21
Q

Suppresses T-lymphocyte response to mitogens
DMARD for RA and malaria
SE: ocular toxicity

Drug

A

Chloroquine
(Hydroxychloroquine)

Safe in pregnant

22
Q

Forms Phosphoramide mustard, crosslinking DNA to prevent replication
DMARD for RA, chemotherapy
SE: hemorrhagic cystitis

Drug

A

Cyclophosphamide

23
Q

Inhibits IL1 and IL2 receptor production
DMARD for RA, tissue transplantation
SE: nephrotoxicity, gingival hyperplasia, hirsutism

Drug

A

Cyclosporine

24
Q

Inhibits Inosine monophosphate dehydrogenase (impt in guanine nucleotide synthesis)
Inhibits T lymphocyte proliferation
Drug for SLE nephritis, RA
SE: reversible myelosuppression (neutropenia)

Drug

A

Mycophenolate Mofetil

25
Q

Inhibits inflammatory cytokines
DMARD for RA, inflammatory bowel disease
SE: hemolytic anemia, methemoglobinemia, reversible infertility in men

Drug

A

Sulfasalazine

26
Q

Inhibits microtubule assembly
Drug for gout, Familial Mediterranean Fever
SE: diarrhea, hepatic necrosis, ARF, agranulocytosis

Drug

A

Colchicine

27
Q

NSAID used as initial treatment of gout as Colchicine replacement

A

Indomethacin

28
Q

Competes with Uric Acid for reabsorption in the proximal tubules
Drug for gout
SI: GI irritation, aplastic anemia
May precipitate acute gout during early phase and inhibits secretion of other weak acids

Drug?

A

Probenecid

Sulfinpyrazone

29
Q

Irreversible Xanthine Oxidase inhibitor
First line tx for Gout, tumor lysis syndrome
SI: cataracts
Witheld 1-2 wks after acute gouty arthritis
Inh metabolism of mercaptopurine and azathioprine

Drug?

A

Allopurinol

30
Q

Reversible xanthine oxidase inhibitor
More selective
Drug for chronic gout, tumor lysis syndrome
Witheld for 1-2 weeks after acute gouty arthritis

Drug?

A

Febuxostat