Anti-Seizure Flashcards

0
Q

Anti-seizure drugs that act on GABA alone

A
Diazepam
Clonazepam
Felbamate
Vigabatrin
Tiagabine

DI ma-CLOse ang Fly, VIG TIAn

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1
Q

Only anti-seizure drug that acts on K

A

Oxcarbazepine

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2
Q

Blocks voltage gated Na channels
Drug for GTC seizures, partial seizures DOC
SE: diplopia (dose-related), gingival hyperplasia, hirsutism, teratogen
CYP450 inducer
Zero Order Kinetics at high doses
Extensively protein bound

A

Phenytoin, Anticonvulsant (hydantoin)

LAHAT NG MAY -YDANTOIN

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3
Q

Blocks voltage gated Na channels and decreases glutamine release
Drug for GTC seizures, partial seizures DOC, trigrminal neuralgia
SE: diplopia (most severe idiosyncratic), ataxia (dose-related), blood dyscrasia, erythematous rash (most common idiosyncratic)
CYP450 inducer
Zero Order Kinetics at high doses
Extensively protein bound

A

Carbamazepine, Anticonvulsant (tricyclic)

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4
Q

Blocks high frequency firing of neurons modifies amino acid metabolism
Drug for GTC seizures, juvenile myoclonic epilepsy, DOC migraine, acute mania
SE: hepatotoxicity (in infants), teratogen (spina bifida), GI distress (most common)
CYP450 inhibitor

A

Valproic Acid, Anticonvulsant (branched chain FA)

Sodium Valproate

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5
Q

Increases duration of chloride channel opening
Long acting drug for seizure disorders (pedia), status epilepticus, hyperbilirubinemias (Gilbert’s Syndrome)
SE: higher likelihood of dependence than benzodiazepines, acute intermittent porphyria
Additive CNS depression with alcohol
Potent inducer of CYP450
Safe for pregnant

Drug, Class

A

Phenobarbital
Primidone

Barbiturates

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6
Q

Decreases Ca2+ currents, T-type in thalamus
DOC for pure absence seizures
SE: GI distress

Drug, Class

A

Ethosuximide, anticonvulsant (cyclic ureide)

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7
Q

Increases frequency of chloride channel opening
DOC for Status epilepticus
SE: anterograde amnesia, unwanted daytime sedation
Additive CNS depression with alcohol

Drug?

A

Diazepam, anticonvulsant (barbiturate)

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8
Q

Increases frequency of chloride channel opening
Highly sedating for absence seizures
SE: anterograde amnesia, unwanted daytime sedation
Additive CNS depression with alcohol

Drug, Class

A

Clonazepam, anticonvulsant (benzodiazepine)

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9
Q

Blocks Ca2+ channels n-type
Drug for neuropathic pain (postherpetic neuralgia), Migraine
SE: dizziness, sedation, ataxia, nystagmus, tremor

Drug, Class

A

Gabapentin, Anticonvulsant (GABA derivative)

Pregabalin

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10
Q

Blocks Na and Ca channels, decreases glutamate
Drug for Bipolar disorder
SE: SJS

Drug, Class

A

Lamotrigine, Anticonvulsant (Phenyltriazine)

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11
Q

Selectively binds SV2A, modifies synaptic release of glutamate and GABA
Adjunct drug for GTC/Partial seizures, Juvenile Myoclonic Epilepsy
Not metabolized by Cytochrome P450

A

Levetiracetam, Anticonvulsant (piracetam)

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12
Q

Anticonvulsant with most number of MOA

A

Topiramate, Anticonvulsant (monosaccharide derivative)

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13
Q

Drug for Lennox-Gastaut Syndrome, GTC, Absence, Partial seizures, migraine prophylaxis
SE: psychomotor slowing, memory impairment, weightliss, acute myopia, glaucoma, urolithiasis

A

Topiramate, Anticonvulsant (monosaccharide derivative)

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14
Q

Drugs for GTC

A

Valproic Acid
Phenytoin
Carbamazepine

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15
Q

Drugs for Partial Seizures

A

Carbamazepine
Lamotrigine
Phenytoin

16
Q

Drugs for Absence Seizures

A

Ethosuximide

Valproic Acid

17
Q

Drugs for Myoclonic and Atypical Absence Syndromes

A

Valproic Acid

18
Q

Drugs for Status Epilepticus

A

Lorazepam
Diazepam
Phenytoin
Phenobarbital

19
Q

Drugs for Trigeminal Neuralgia

A

DOC Carbamazepine

Oxcarbazepine

20
Q

Drugs for Neuropathic Pain

A

Gabapentin

Pregabalin

21
Q

Drugs for Migraine

A

Gabapentin
Phenytoin
Topiramate
Valproic Acid

22
Q

Drugs for Bipolar Affective Disorder

A

Valproic Acid (First-line)
Carbamazepine
Lamotrigine