Recombinant cytokines and therapeutic antibodies

Question 1

Aldesluekin (IL2)

Answer 1

renal cell carcinoma, metastatic melanoma

Question 2

Epoetin alfa (EPO)

Answer 2

anemia (esp in renal failure)

Question 3

Filgrastim (G-CSF)

Answer 3

Recovery of bone marrow

Question 4

Sargramostim (GM-CSF)

Answer 4

Recovery of bone marrow

Question 5

Alpha interferon

Answer 5

HepB and C, kaposi’s sarcoma, leukemias, malignant melanoma

Question 6

Beta interferon

Answer 6

Multiple sclerosis

Question 7

gamma interferon

Answer 7

CGD

Question 8

Oprelvekin (IL 11)

Answer 8

Thrombocytopenia

Question 9

Thrombopoietin

Answer 9

Thrombocytopenia

Question 10

Muromonab-CD3

Answer 10

Targets CD3

Prevents acute transplant rejections

Question 11

Infliximab

Answer 11

Target TNFa

Crohns’ RA, psoriatic arthritis, ankylosing spondylitis

Question 12

Adalimumab

Answer 12

Target TNFa

Crohns’ RA, psoriatic arthritis, ankylosing spondylitis

Question 13

Abciximab

Answer 13

Target Glycoprotein IIb/IIIa

Prevents cardiac ischemia in unstable angina and in pts treated with percutaneous coronary intervention

Question 14

Transtuzumab (herceptin)

Answer 14

Target HER2

HER2 overexpressing breast cancer

Question 15

Rituximab (CD20)

Answer 15

B cell, non Hodgkin’s lymphoma

Question 16

Omalizumab (IgE)

Answer 16

Additional line of treatment for severe asthma