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STEP1: immuno and path > Carcinogens > Flashcards

Carcinogens Flashcards

1
Q

Alkylating agents

A

Blood

Leukemia and lymphoma

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2
Q

Aromatic amine

A

Bladder

Examples: bendizine, 2-naphthylamine
Transitional cell carcinoma

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3
Q

Arsenic

A 
Liver = angiosarcoma
Lung= lung cancer
Skin= squamous cell carcinoma
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4
Q

Asbestos

A

Lung

Bronchogenic carcinoma> mesothelioma

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5
Q

CCl3

A 
Liver
Centriolobular necrosis (Zone III)
fatty change
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6
Q

Cigarette

A 
Bladder = transitional cell carcinoma
Esophagus = SCC/adenocarcinoma
Kidney = RCC
Larynx = SCC and SCC
Pancreas= pancreatic adenocarcinoma
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7
Q

Ethanol

A

Liver = HCC

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8
Q

Ionizing agents

A

Thyroid

Papillary thyroid carcinoma

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9
Q

Nitrosamines

A

Gastric cancer

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10
Q

Radon

A

Lung cancer,

2nd leading cause after cigarette

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11
Q

Vinyl chloride

A

Liver

Angiosarcoma

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12
Q

Paraneoplastic syndrome:

Hypercalcemia

A

Elevated calcitriol

Hodgkin and some non Hodgkins

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13
Q

Paraneoplastic syndrome:

Cushing

A

Small cell lung carcinoma

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14
Q

Paraneoplastic syndrome:

SIADH

A

Small cell lung carcinoma

Intracranial neoplasms

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15
Q

Paraneoplastic syndrome:

Lambert-Eaton myasthenic syndrome

A

Small cell lung carcinoma

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16
Q

Paraneoplastic syndrome:

Polycthemia

A

EPO

RCC, thymoma, hemangioblastoma, HCC, leiomyoma, pheo

17
Q

Paraneoplastic syndrome:

Hypercalcemia

A

PTHrP

SCC of lung cancer,
RCC
Breast Ca

18
Q

Psammoma bodidies

A

Papillary carcinoma of thyroid
Serous papillary cystadenoma of ovary
Meningioma
Malignant mesothelioma

19
Q

Cancer epidemiology

A

Incidence:
Male: prostate > lung > colon/rectum
Female: breast> lung> colon/rectum
*lung cancer incidence dropped in men, but has not changed in women

Mortality
Male: lung> prostate
Female: lung> breast
*cancer is the 2nd leading cause of death in the US,
CV is the 1st.

STEP1: immuno and path (15 decks)

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