Drugs used in Obesity Flashcards
What are the three reasons why resistance to leptin arises?
- decreasing sensitivity of leptin receptor in hypothalamus
- secondary message signals less sensitive
- transport system reduce sensitivity - less leptin in the brain
What are six conditions that excess body fat predispose people to?
Type 2 Diabetes
Coronary Heart Disease, Hypertension
Cancer
Asthma
Sleep apnoea
Osteoathritis
What happens after a high fat meal when on Orlistat?
Explosure diarrhoea
Fat leakage
Describe the circadian rhythm of leptin
High at midday
Low in midnight
What is the mechanism of function of phentermine?
Act in the brain to increase NA, serotonin and dopamine to cause reduced food intake
Which drug can’t you use with phentermine?
MAO inhibitors (anti-depressant)
What are the weight loss effects of topiramate?
Increase energy expenditure
Suppress appetite
(Reduce insulin resistance)
What are the side effects of phentermine?
Increased BP, HR
Insomnia
Anxiety
Dry Mouth
Headache
What is the function of amylin?
Inhibit glucagon release
Delay gastric emptying
Inhibit food intake
Why doesn’t targeting single neuropeptides work in reducing appetite?
Because there are multiple so others will compensate
What is the advantage of Centilistat?
Less side effects cf to orlistat with the same general function
What are target general strategies to target excess weight?
Reduce food intake
Reduce fat absorption
Increase thermogenesis
How does leptin pass the BBB?
A specific channel
Why can you only use phentermine for 3 weeks?
Tolerance develops
How much does Orlistat reduce fat absorption?
By 30%
