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Biochemistry > FA metabolism > Flashcards

FA metabolism Flashcards

1
Q

Long chain FA are activated in the cytosol by how many ATP?

A

2 ATPs

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2
Q

Where does FA oxidation occur?

A

Mitochondrial matric

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3
Q

Where does FA synthesis occur?

A

Cytosol

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4
Q

Where does MalonylCoA inhibit?

A

CPT I

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5
Q

Which shuttle is used in FA synthesis?

A

CItrate shuttle

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6
Q

Which shuttle is used in FA oxidation?

A

Carnitine

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7
Q

What is the rate determining enzyme in FA oxidation?

A

Carnitine acyltransferase I (CPTI)

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8
Q

What is the rate limiting enzyme in FA synthesis?

A

AcCoA carboxylase (ACC)

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9
Q

What step is AcCoA denhydrogenase used in for FA oxidation?

A

Step 1: FattyacylCoA to trans FattyenolCoA

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10
Q

What enzymes are needed for oxidation of unsaturated FAs?

A
  1. enoylCoA isomerase
  2. 2,4-dienoyl reductase
  3. acylCoA dehydrogenase
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11
Q

What does B-oxidation of odd-chain FAs produce?

A

AcCoA + propionylCoA

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12
Q

How does propionylCoA enter the TCA cycle?

A

PropionylCoA—–> MethylmalonylCoA + B12—->Succinyl CoA

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13
Q

What does Beta Oxidation produce?

A

AcCoA

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14
Q

How many each mol of AcCoA produces how many ATPs?

A

10

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15
Q

Every 2 carbons of a FA produces?

A

1 FADH–>2 ATP, 1 NADH—>3 ATP, and 1 AcCoA–>10 mol of ATP. =15 moles

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16
Q

omega-oxidation occurs where in the cell?

A

Smooth Endoplasmic Reticulum

17
Q

Where are VLFAC oxidized?

A

Peroxisomes

18
Q

What are the fates of AcCoA?

A
  1. Ketone bodies (liver)

2. TCA cycle

19
Q

What are the two main ketone bodies?

A
  1. acetoacetate
  2. Beta-hydroxybutyrate
    (used in muscle and brain)
20
Q

What stimulates synthesis of Ketone Bodies in liver?

A

High ration of NADH/NAD which slows down TCA cycle causing AcCoA buildup

21
Q

Which enzyme is needed to use ketones?

A

thiotransferase which is not in the liver

22
Q

What is the purpose of ketone bodies?

A

Spares muscles during starvation

Biochemistry (6 decks)

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