FUO Sepsis

Question 1

Define antigen

Answer 1

Any foreign substance that stimulates the body’s immune system to produce antibodies

Question 2

Define antibody

Answer 2

A protein produced by the body’s immune system in response to a foreign substance (antigen)

Question 3

Define Innate (Nonspecific) host defense

Answer 3

General defense that responds immediately to challenge regardless of previous exposure to it

Question 4

Define adaptive (Specific defenses)

Answer 4

Specialized defense

Response to specific challenge

Question 5

Define complement system

Answer 5

Part of the innate immune system; defense against pyogenic organisms
(it promotes inflammatory resp)

Question 6

Describe the IgG antibody

Answer 6

• Fights bacterial and viral infections

- only type of antibody that can cross the placenta

Question 7

Describe the IgM antibody

Answer 7

• Blood and lymph fluid

- First type of antibody made in response to an infection

Question 8

Describe the IgA antibody

Answer 8

• Predominant antibody class in secretions
• Respiratory, GI tract, ears, eyes, vagina
• Protect body surfaces exposed to outside foreign substances

Question 9

Describe the IgE antibody

Answer 9

role in immune responses to parasites & allergic reactions

Question 10

Describe the IgD antibody

Answer 10

low levels in serum, role uncertain

Question 11

Define fever

Answer 11

An elevation in core body temperature above the daily range for an individual

Question 12

Define fever of unknown origin (FUO)

Answer 12

temperature greater than 38.3°C (101°F) on several occasions

Question 13

What are the criteria for FUO?

Answer 13

(1) Temp greater than 38.3 (101) on several occasions
(2) more than 3 weeks’ duration of illness,
(3) failure to reach a diagnosis despite 1 week of inpatient investigation.

Question 14

Define Sepsis

Answer 14

Systemic Inflammatory Response (SIRS) due to infection

Question 15

Define severe sepsis

Answer 15

Severe sepsis plus hypotension