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Flashcards in 27 - adverse drug reactions Deck (14)
1

def adverse drug reaction

bad and unintended effect when used the drug as approiate

2

side effect

unintended effect that is predictable

3

adverse drug event

any undesirable event that was unintended and preventable due to error

4

**6 most common presentations

1. hypoglycemia
2. hypotension
3. coagulopathy or hemmorage
4. rash
5. mental status change
6. GI Sx

5

5 etiologies of ADRs (ABCDE)

A- augmented
- dose dependent and predictable
- dose adust
B- bizarre
- idiosyncratic and unpredictable
- anaphylaxis
C - chronic
- cumulative dose related
- prolong withdrawal
D - delayed
- late effects
- terato, carcino
E - end of use
- withdrawal effects

6

6 physician behavs that can reduce

1. proper documentation of meds and herbals
2. proper documentation of PT variable
- allergies, preg, breastfeed, renal imparimen
3. chec drug interactions
4. dose adjust for renal impariment
- Cr and Cr clearance
5. explain drug and SEs to patient
6. review med list for poly pharma

7

4 most common drugs with ADRs

1. ASA
2. warfarin
3. NSAIDs
4. diuretics

8

4 most common causes of death

1. GI bleeds
2. perforated PUD
3. IC hemorrage
4. renal failure

9

def serotonin syndrome

type A ADR with 2 or more serotonin drugs at once

10

triad of serotonin syndrome

1. altered mental status
2. ANS dysfunction
- fever, chills, diarrhea, tachy
3. neuromuscular abnormalities

11

mgmt of serotonin

1. avoid and recognize
2. stop drug
3. resus
4. RO infection, metabolic, endo
5. antoserotinergics

12

what is drug induced long QT

1. repol. is through K channels
- blockade leads to long QT
type A ADR

13

drugs causing long QT

1. antiarrythmics class 3
- amiodarone, procainamide
ANTIARRYTHMICS ARE PROARRYTHMIC
2. antipsyh
3. ABx - macro and flouro
4. antimalarials
5. antifungals
6. antihistamines

14

what is ABx induced diarrhea

- usually by C difficile
pain, fever, fould smelling diarrhea
- spore forming