27 morph Flashcards Preview

msk2 > 27 morph > Flashcards

Flashcards in 27 morph Deck (21)
Loading flashcards...
1

inflamm and demyelination of spinal n. roots and peripheral nn. (radiculoneuropathy)

Guillain-Barre Syndrome

2

ab and t cell response

-Guillain-Barre Syndrome
-Chronic Inflamm. Demyelinating Poly(radiculo)neuropathy

3

Recurrent demyelination, remyelination, and Schwann cell proliferation that leads to onion bulbs

Chronic Inflamm. Demyelinating Poly(radiculo)neuropathy
=excessive prolif=Schwann cells wrap around an axon like layers of an onion

4

fibrosis/thickening of endo/perineural sheath

-lepromatous leprosy
-tuberculoid leprosy

5

Tomaculi: Swollen, bulbous myelin sheaths at the end of internodes.

Hereditary Neuropathy with Pressure Palsy

6

perifascicular atrophy

dermatomyositis

7

Tubuloreticular endothelial cell inclusions (type I IFN response).

dermatomyositis

8

Abnormal cytoplasmic inclusions (rimmed vacuoles)

Inclusion Body Myositis

9

Aggregation of whorled, lamellar membranous structures (curvilinear bodies).

Toxic Myopathies (progressive m weakness)

10

• Chronic mm. damage outpaces the repair capacity.
• Segmental myofiber degeneration and regeneration
• --> mm. is replaced by collagen and fat cells ('fatty replacement').
• Remaining myofibers vary in size (small/atrophic to large/hypertrophied) => distorted fascicular architecture

X-linked Muscular Dystrophy (Duchenne & Becker MD)

11

 Abnormal aggregates of mitochondria seen in the subsarcolemmal area of affected myofibers of skeletal mm. ('ragged red fibers')

Mitochondrial Myopathies

12

Phonograph records: abnormal mitochondria with concentric membranous rings.

Mitochondrial Myopathies

13

Rhomboid para-crystalline inclusions

Mitochondrial Myopathies

14

o Antoni A areas: admixture of dense areas
o Antoni B areas: admixture of loose areas (hypocellular)

schwannoma

15

cells: presence of a spindled, elongated nucleus w a wavy or buckled shape

schwannoma

16

pedunculated nodule in dermis and SQ fat w loose collagen

superficial cuteneous neurofibroma

17

lg plaquelike elevation of skin

diffuse neurofibroma

18

tumors that entrap axons; multiple fassicles= bag of worms; collagen = shredded carrots

plexiform neurofibroma

19

nodular ingrowth of Schwann cells into the spinal cord.

Schwannosis (of NF2)

20

proliferation of meningeal cells and blood vessels growing in the brain

Meningioangiomatosis (of NF2)

21

microscopic nodular collections of glial cells at abnormal locations (superficial or deep cerebral cortex).

Glial harmartia (of NF2)