Flashcards in 27 morph Deck (21)
inflamm and demyelination of spinal n. roots and peripheral nn. (radiculoneuropathy)
ab and t cell response
-Chronic Inflamm. Demyelinating Poly(radiculo)neuropathy
Recurrent demyelination, remyelination, and Schwann cell proliferation that leads to onion bulbs
Chronic Inflamm. Demyelinating Poly(radiculo)neuropathy
=excessive prolif=Schwann cells wrap around an axon like layers of an onion
fibrosis/thickening of endo/perineural sheath
Tomaculi: Swollen, bulbous myelin sheaths at the end of internodes.
Hereditary Neuropathy with Pressure Palsy
Tubuloreticular endothelial cell inclusions (type I IFN response).
Abnormal cytoplasmic inclusions (rimmed vacuoles)
Inclusion Body Myositis
Aggregation of whorled, lamellar membranous structures (curvilinear bodies).
Toxic Myopathies (progressive m weakness)
• Chronic mm. damage outpaces the repair capacity.
• Segmental myofiber degeneration and regeneration
• --> mm. is replaced by collagen and fat cells ('fatty replacement').
• Remaining myofibers vary in size (small/atrophic to large/hypertrophied) => distorted fascicular architecture
X-linked Muscular Dystrophy (Duchenne & Becker MD)
Abnormal aggregates of mitochondria seen in the subsarcolemmal area of affected myofibers of skeletal mm. ('ragged red fibers')
Phonograph records: abnormal mitochondria with concentric membranous rings.
Rhomboid para-crystalline inclusions
o Antoni A areas: admixture of dense areas
o Antoni B areas: admixture of loose areas (hypocellular)
cells: presence of a spindled, elongated nucleus w a wavy or buckled shape
pedunculated nodule in dermis and SQ fat w loose collagen
superficial cuteneous neurofibroma
lg plaquelike elevation of skin
tumors that entrap axons; multiple fassicles= bag of worms; collagen = shredded carrots
nodular ingrowth of Schwann cells into the spinal cord.
Schwannosis (of NF2)
proliferation of meningeal cells and blood vessels growing in the brain
Meningioangiomatosis (of NF2)