Flashcards in tx Deck (6)
Cured if detected early
Drugs that target RAS and P13K/AKT pathways
Anti-CTLA4 blocking antibodies
Anti-PD1 blocking antibodies
o Local eradication is indicated.
o Curettage, freezing or topical chemo.
o Topical imiquimod activates TLRs and eradicates 50% of lesions (via activation of immune cells).
Tx targeting the inhibition of Hedgehog pathway have excellent responses in pts with locally aggressive or metastatic dz.
o Wide local excision.
o If unresectable d/t location or spread, use PDGFβ inhibitors (imatinib drug d/c and tumor recurs so pts use this drug for life)
Acute Eczematous Dermatitis
Tx with steroids is palliative (not curative), need to remove offending substance from the environment.