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Flashcards in tx Deck (6)
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1

melanoma

 Cured if detected early
 Drugs that target RAS and P13K/AKT pathways
 BRAF inhibitors
 Anti-CTLA4 blocking antibodies
 Anti-PD1 blocking antibodies

2

actinic keratosis

o Local eradication is indicated.
o Curettage, freezing or topical chemo.
o Topical imiquimod activates TLRs and eradicates 50% of lesions (via activation of immune cells).

3

BCC

Tx targeting the inhibition of Hedgehog pathway have excellent responses in pts with locally aggressive or metastatic dz.

4

Dermatofibrosarcoma Protuberans

o Wide local excision.
o If unresectable d/t location or spread, use PDGFβ inhibitors (imatinib drug d/c and tumor recurs so pts use this drug for life)

5

Acute Eczematous Dermatitis

Tx with steroids is palliative (not curative), need to remove offending substance from the environment.

6

phemigus

immunosuppression