28 - ECM Flashcards by Jason Yin

Q

What is the ECM broadly? What important macromolecules does it contain? What does it do?

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Do you know these?

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review

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Q

What is the structure and function of collagen? Where is it found?

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Q

How is collagen synthesized?

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Q

What residues make up collagen? Why is this important?

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Q

How is the triple helix stabilized and strengthened (overview)?

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Q

What is fibrillar collagen?

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Q

What are the types of collagen?

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Q

What are some structural variations in collagen?

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Q

What are elastic fibers (overview)? Where are they found? What are their general structure, composition, and function?

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Q

What is a disease associated with improper elastic fiber production?

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Q

What is fibronectin? What is it used for? What is its general structure and function?

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Q

What are fibronection isoforms? How are they made? What are the consequences of this?

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Q

What does mutations in fibronection formation cause?

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Q

What are proteoglycans? General structure and function?

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Q

What are glycosaminoglycans (GAGs)? General structure and function? Common ones?

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Q

What is the basement membrane generally? What is it composed of/contain? General structure and function?

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Laminins, type 4 collagen, perlecan, nidogen (entactin)

Q

What are laminins?

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What is type 4 collagen?

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What is perlecan? What do mutations in perlecan result in?

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Q

What is nideogen (entactin)? General structure and function?

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Q

What is the function role of the basal lamina (which contains the basement membrane)?

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Q

What is Alport’s syndrome? What does it affect? Common symptoms?

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Q

Why is ECM remodeling necessary? How is it performed? What molecules are most relevant?

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What are matrix metalloproteinases (MMPs)? What do they do? How are they classified?

What is the structure of MMPs? How does that relate to their function?

What are some relatives of MMPs (molecules with similar function of MMPs)? What are the structural similarities?

What are TIMPs (tissue INHIBITORS of metalloproteinases)?

How do MMPs and TIMPs function in development and disease?

What are the modes of action of MMPs?

How does epithelial branching morphogenesis depend on the balance of MMPS and TIMPs?

What is the role of MMPs in dermal wound healing?

What is the role of MMPs in the replacement of normal tissue with fibrotic tissue?