Acne- Pharm

Question 1

Benzoyl Peroxide- Indications

Answer 1

Mild, mixed acne- inflammatory & comedones

Question 2

Benzoyl Peroxide- MOA

Answer 2

Unknown- keratolytic & antibacterial

Question 3

Benzoyl Peroxide- AE

Answer 3

Contact dermatitis, xeroderma, erythema, peeling

Question 4

Retinoids- Indications

Answer 4

Mild non to mild mixed acne

Question 5

Retinoids- MOA

Answer 5

Unknown- epithelial cell turnover

Question 6

Retinoids- Names

Answer 6

Tretinoin, adapalene

Question 7

Retinoids- AE

Answer 7

Photosensativity, peeling, zeroderma, bruning, erythema, pruritis

Question 8

Clindamycin Topical- Indications

Answer 8

Mild mixed to deep inflammatory acne

Question 9

Clindamycin Topical- MOA

Answer 9

Inhibits P. acnes- antiinflamatort

Question 10

Clindamycin Topical- AE

Answer 10

Increased resistance. Use in conjunction with BPO.

Question 11

Erythromycin Topical- Indications

Answer 11

Mild to moderate acne

Question 12

Erythromycin Topical-MOA

Answer 12

Antimicrobial and anti-inflammatroy

Question 13

Erythromycin Topical- AE

Answer 13

Increased resistance. Use in conjunction with BPO.

Question 14

Tetracycline- AE

Answer 14

Pregnancy & children with out all adult teeth- tooth discoloration

Question 15

Tetracycline- Indications

Answer 15

Moderate to severe acne

Question 16

Moderate to severe acne MOA

Answer 16

Antimicrobial & anti-inflamatory properties

Question 17

Minocycline- Indications

Answer 17

Deep inflammatory, moderate, non-scarring acne, in conjunction with topical abx.
More effective than tetracycline

Question 18

Minocycline- MOA

Answer 18

Bacteriostatic, inhibits protein synthesis

Question 19

Minocycline- AE

Answer 19

Resistance, candidiasis, GI, HA

Question 20

Doxycycline- Indications

Answer 20

Deep inflammatory, moderate, non-scarring acne, in conjunction with topical abx.

Question 21

Doxycycline- MOA

Answer 21

Bacteriostatic, inhibits protein synthesis

Question 22

Doxycycline- AE

Answer 22

photosensitizing, same but fewer than minocycline

Question 23

Tetracycline- Indication

Answer 23

Deep inflammatory, moderate, non-scarring acne, in conjunction with topical abx.

Question 24

Tetracycline- MOA

Answer 24

Bacteriostatic, inhibits protein synthesis

Question 25

Tetracycline- AE

Answer 25

more common than other orals, must take on empty stomach- no dairy

Question 26

Macrolides- Indications

Answer 26

Moderate to severe acne

Question 27

Macrolides- MOA

Answer 27

antimicrobial & anti-inflammatroy

Question 28

Macrolides- AE

Answer 28

GI distress, hepatotoxicity

Question 29

Isotretinonin- Acutane- Indications

Answer 29

Severe nodulocystic acne, resistance to conservative tx

Question 30

Isotretinonin- Acutane- MOA

Answer 30

Decreases sebum production, not well understood

Question 31

Isotretinonin- Acutane- AE

Answer 31

-Teratogenicity!! xerosis, chelitis, blepharconjunctivitis, epitaxis - depression/ suicide? -IBD? - Elevated liver enzymes, myaglia, arthralgia elevated triglycerides

Question 32

Isotretinonin- Acutane- Pt Ed

Answer 32

Must not become pregnant- category X, depression/ suicide risk. Must be on 2 contraceptives, monthly monitoring

Question 33

Oral contraceptives- Indications

Answer 33

Females for flares, persistant inflammatory papules on jaw, neck, back

Question 34

Oral contraceptives- Types

Answer 34

Spironolactone- potassium sparing diuretic | BCP- suppress androgen production

Question 35

Salicylic acid- Indications

Answer 35

Mild, non-inflammatroy acne

Question 36

Salicylic acid- MOA

Answer 36

keratolytic, epidermal cell removal

Question 37

Salicylic acid- AE

Answer 37

Irritation, stinging, burning, acidosis or alkalosis