2th Flashcards
Method of absorption for vitB12 and intrinsic factor
Endocytosis
VitB12 and intrinsic factor absorption site
Terminal ileum
Which is better at absorption solutions or suspensions
Solutions
Sustained-release preparations absorption rate?
Slow in absorption
Disintegration and dissolution rate for paracetamol and digoxin?
Rapid with paracetamol and slow with digoxin
Quarternary ammonium Compounds ionization form
Always ionized (poor absorption)
Tertiary amines (physostigmine)
Always unionized (better absorption)
Aspirn is acidic or basic?
Acidic
Amphetamine is acidic or basic?
Basic
Streptomycin ionization and absorption
High pka»ionized»_space;poor absorption
Ion trapping aspirin cause what
Peptic ulceration
Route of administration absorption rate
IV>inhalation >IM>SC>Oral>skin
Absorbing surface vascularity absorption rate
Alveoli>skeletal muscles >subcutaneous
Surface area absorption rate
Intestines >stomach
What happens to absorption rate during diarrhea and malabsorption
Decrease in oral absorption
What happens to absorption rate during shock and heart failure
Decrease in absorption
Vit.B12 specific factor
Intrinsic factor
Vit.C increase the absorption of what
Iron
What does the activated charcoal do to oral absorption
Decrease oral absorption of most drugs
Impact of SC adrenaline to absorption rate
VC»>decrease absorption rate of local anesthetics»longer action duration
Transdermal drugs E.g
Nitroglycerin,estrogen
Irritant drugs that mustn’t be taken on empty stomach
Aspirin
What decrease the oral absorption of tetracycline
Milk(calcium)
Gastric acidity (pH) increase the absorption of what drugs
Acidic drugs: aspirin barbiturates
