3th

Question 1

What separates body compartments

Answer 1

Capillary walls and cell membranes

Question 2

One compartmental model drugs (trapped in plasma compartment)

Answer 2

Heparin&dextran

Question 3

Two compartmenal model (ECF) drugs

Answer 3

Aminoglycoside & mannitol

Question 4

Multi-compartemntal model(ECF+ICF)

Answer 4

Ethanol & sulphonamide

Question 5

Tissue reservior:iodine

Answer 5

Thyroid & salaivary glands

Question 6

Tissue reservior: calcium and tetracycline

Answer 6

Bones & teeth

Question 7

Tissue reservior: chloroquine

Answer 7

Liver

Question 8

Tissue reservior: thiopental

Answer 8

Fat

Question 9

Vd doesn’t describe real volume but what

Answer 9

Ratio of drug in the extraplasmic spaces relative to the plasma space

Question 10

Small Vd drug

Answer 10

Frusemide

Question 11

Large Vd drug

Answer 11

Digoxin

Question 12

When is dialysis isn’t useful

Answer 12

For high Vd drugs (most of the drugs are in the tissue)

Question 13

What kind of drugs bind mainly with albumin

Answer 13

Acidic and lipophilic

Question 14

What is prefusion

Answer 14

Amount of drug which is delivered to a particular organ depending on blood flow

Question 15

E.g on hypoalbuminemia

Answer 15

Starvation & malnutrition

Question 16

Drug that becomes toxic if there’s hypoalbuminemia

Answer 16

Phenytoin

Question 17

Competition on plasma proteins: sulphonamide & aspirin displace what

Answer 17

Warfarin»bleeding

Question 18

Competition on plasma proteins: sulphonamide displace what

Answer 18

Bilirubin»kernicterus in premature neonates

Question 19

Passage of drugs to CNS lipid soluble

Answer 19

general anesthetics & CNS depressants

Question 20

Passage of drugs to CNS 3ry amines and 4ry NH4

Answer 20

3ry amines can pass
4ry NH4 CANNOT

Question 21

Passage of drugs to CNS some hydrophilic

Answer 21

Antibiotics: penicillin (inflamed BBB only)

Question 22

How drugs pass the placental barrier

Answer 22

Simple diffusion

Question 23

Passage of drugs to fetus: drugs given in 3th to 10th week of pregnancy

Answer 23

Teratogenicity (thalidomide»phocomelia)

Question 24

Passage of drugs to fetus: oral anticoagulants

Answer 24

Fatal hemorrhage

Question 25

Passage of drugs to fetus: oral hypoglycemics

Answer 25

Prolonged neonatal hypoglycemia

Question 26

Passage of drugs to fetus: aminoglycosides

Answer 26

8th cranial nerve damage

Question 27

Passage of drugs to fetus: during labor, morphine

Answer 27

Respiratory depression (asphyxia neonatorum)

Question 28

Passage of drugs to breast milk: sedatives,hypnotics,narcotics

Answer 28

CNS depression in baby

Question 29

Passage of drugs to breast milk: oral penicillins & purgatives

Answer 29

Diarrhea in baby

Question 30

Passage of drugs to breast milk: anticancer drugs

Answer 30

Decrease growth in baby

Question 31

Passage of drugs to breast milk: bromocriptine & sex hormones

Answer 31

Suppress lactation