3 Coagulation Workshop Flashcards Preview

Clinical > 3 Coagulation Workshop > Flashcards

Flashcards in 3 Coagulation Workshop Deck (20):
1

Venous thromboembolism results from....
Where as arterial results from ....

Venous: poor blood flow (immobility, dehydration)
Arterial: hyeprcoagulability, vascular injury

2

How are e structures of a venous and arterial thromboembolism different?

Venous has low platelet content (red thrombus)
Arterial has larger platelet content (white thrombus)

3

Three was to treat thrombus

Modify blood coagulation (i.e. fibrin formation)
Modify platelet function
Modify fibrin removal (i.e. fibrinolysis)

4

Anticoagulants or antiplatelets are used for the treatment of arterial thrombus

Antiplatelets for arterial – MI and Stroke

5

After major surgery the risk of PE increases

10 fold

6

Infection increases PE risk .... fold and admission increases risk....fold

2
10

7

Venous thromboembolism results in ..... Where as arterial results in....

Venous: PE and DVT
Arterial: MI and stroke

8

Outline the clotting pathway

Extrinsic - VII to X
Intrinsic - XII to XI to IX to X to prothrombin to fibrinogen to clot

9

What is the mode of action of clopidogrel?

Inhibits platelet aggregation by inhibiting ADP binding

10

What is the mode of action of prasugrel and ticagrelor?

Inhibits platelet aggregation by inhibiting P2Y binding

11

What is the mode of action of aspirin

Inhibits Cox preventing the synth of PG and thromboxane.

12

Risk factors for venous thrombosis 7

HRT/COC
Age over 60
Immobility after surgery
Obesity
Dehydration
Comorbidities (Cancer, MI, IBS)
Smoking?

13

INR is a measure of the ...... pathway

..?

14

When to use d dimer?

To exclude PE in a low Well's score

15

Diagnosis for PE is obtained by...

Well's score low exclude with d dimer
Well's score high use CTPA scan (or VQ scan if young).

16

When dosing fatties in the exam write

Seek specialist advice regarding her weight

17

How long to continue LMWH when starting warfarin

At least five days and until INR is over two for two consecutive for days

18

Anticoagulant of choice in preg

LMWH

19

Anticoagulants for breast feeding

Heparin and warfarin

20

Future pregnancies after a previous VTE treatment.,?

Prophylactic dose starting 4 weeks before time of last VTE in preg. If happens again move to treatment dose.