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Flashcards in 3. Dom Lahey Deck (45):
1

What is the general function of the immune system?

storage of lymphocytes, increase number of lymphocytes, provide favorable environment for establishing immunity

2

Surface protection, acute inflammation, compliment process, lysosome production, and natural barriers describe what type of immunity?

innate

3

Humoral and Cell-Mediated are 2 examples of what type of immunity?

aquired (adaptive)

4

Response to invading bacteria, mediated by B cells/plasma cells, and involves antibody production is which form of adaptive immunity?

humoral

5

Usually response to virus, fungi, foreign cells, mediated by T lymphocytes, does NOT depend on B lymphocyte participation, and cytotoxic response is which type of adaptive immunity?

cell mediated

6

No/incomplete capsule, humoral immunity describes what?

diffuse lymphatics

7

Gastrointestinal, respiratory, urogenital tracts…secretory IgA = secreted on to free epithelial surfaces (tears, saliva, gut lumen, nasal, vaginal)
- FIRST line of defense against infection (antigen specific)...what is this?

MALT

8

Gastrointestinal tract (individual lymph nodules, Peyer’s patches)...is what?

GALT

9

Respiratory lymph nodules, form when air tubes bifurcate...is what?

BALT

10

Roof of nasopharynx, called Adenoids when inflamed, can cause ear-infection describes which form of tonsils?

pharyngeal tonsils

11

Surface epithelium in the pharyngeal tonsil are what type of cells?

respiratory epithelium

12

Boundary of oral cavity/oropharynx, partial capsule likely describes what type of tonsils?

Palatine Tonsils (Tonsilar Crypts)

13

Surface epithelium in the palatine tonsils are what type of cells?

stratified squamous

14

Advantages and disadvantages of the palatine tonsils are what?

advantages - more SA for detecting foreign antigens and lymph node formation

disadvantages - deep depressions (bacteria can thrive = infection = tonsillitis)

15

The tonsil that is on the dorsal posterior 1/3 of tongue (oral cavity) is what?

Lingual Tonsils (Tonsilar Crypts)

16

Surface epithelium in the lingual tonsils are what type of cells?

stratified squamous

17

The tonsillar ring around openings to digestive/respiratory system is referred to as what?

Waldeyer’s Ring

18

Which organs have a capsule, both humoral and cell-mediated immunity?

lymphatic organs

19

Which type of lymphoid organs provide environment where lymphocytes become immunocompetent (thymus and bone marrow)?

primary

20

Which type of lymphoid organs provide an environment where lymphocytes can contact foreign antigens and interact with each other (spleen and lymph nodes)?

secondary

21

What is the function of the lymph nodes?

filtration of lymph using phagocytosis, establish humoral/CM immunity

22

Which lymph node structure is described...dense irregular CT of moderate thickness (trabecular)?

capsule (septa)

23

Which lymph node structure is described...in-coming vessels, contain valves?

afferent lymphatics

24

Which lymph node structure is described... out-going vessels, contain valves?

efferent lymphatics

25

Which lymph node structure is described...recessed area where efferent lymph exits, blood enters/exits?

Hilum

26

Marginal sinus and the first to receive afferent lymph is what type of sinus?

Subcapsular sinus

27

Which type of sinus passes thru the cortex region?

Cortical sinus

28

Which type of sinus passes thru the deep cortex/paracortex region?

Deep cortical sinus

29

Which type of sinus passes thru the medulla region?

Medullary sinus

30

Regions and cells of a lymph nod, within ALL regions/sinuses are supported by system of what type of fibers and cells?

reticular fibers produced by reticular cells

31

-Primary cell type = B lymphocyte
-Activity = phagocytosis and humoral immunity (primarily IgG)

This describes which part of the lymph node?

cortex

32

AKA thymus dependent zone AKA deep cortex
-Primary cell type = T lymphocyte
-Activity = phagocytosis, cell-mediated immunity (long-term storage T cells)

This describes which part of the lymph node?

paracortex

33

Primary cell type = Plasma cells
Activity = phagocytosis, some cell-mediated immunity
* mostly humoral immunity because of ANTIBODY secretion

This describes which part of the lymph node?

medulla

34

Which structure has 2 lobes extending over the great heart vessels, primary lymphoid organ, involution starts after puberty?

thymus

35

What organ's function is to establishment of immunocompetent T lymphocytes? It can distinguish self from non-self antigens to develop self tolerance.

thymus

36

T lymphoblast in the thymus is called what?

thymocyte

37

contains high cell concentration, large # of T lymphatics and macrophages, TEC types 1,2,3
* support using cytoplasmic processes, important blood-thymic barrier

This describes which part of the thymus?

cortex

38

contains lower cell density, fewer but larger T cells, macrophages, APC (dentritic cells), TEC types 4,5,6
* form thymic corpuscles

This describes which part of the thymus?

medulla

39

What cells are produced in bone marrow, enter thymus as immonincompetent cells, and then leaves bloodstream at corticomedullary line?

T Lymphocytes

40

What area of Spleen has areas of concentrated WBCs, primarily lymphocytes?

white pulp

41

What is the function and area of the Spleen that the white pulp is located?

Function = immunity
Areas = next to capsule and setpa, splenic nodules, periarteriolar lymphoid sheaths (surround central arteries, cell-mediated)

42

What is the area of the Spleen that is not white pulp or CT (most of spleen is RED)

red pulp

43

What is the function of the red pulp of the spleen?

rapid blood filtration, contact with blood-born foreign antigens

44

Caused by Epstein-Barr virus (EBV) in mucus/saliva. First replicates in nasopharyngeal epithelium, Can spread to salivary glands, lymph nodes and oropharyngeal lymphoid tissues, Then to liver, spleen, B cells, and blood. What diseases does this describe?

infectious mononucleosis

45

Blood changes: increase in number of platelets and abnormal RBC’s and
Infection: Increased risk of bacterial septicemia especially in children with Strep Pneumo

These condition typically lead to what?

splenectomy