3. Lipids Flashcards

1
Q

What are fatty acids?

A

Hydrophobic hydrocarbon chain with a terminal carboxyl group

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2
Q

What is a saturated fatty acid?

A

Single carbon bonds only

High flexible due to free rotation around single bonds

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3
Q

What are unsaturated fatty acids?

A

Contain one or more double bond
If there are more than one the bonds are placed at 3 carbon intervals
Position is specified by distance from carboxy end

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4
Q

What are essential fatty acids?

A

Cannot be made in the body

Linoleic acid and alpha linolenic acid

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5
Q

What conditions are associated with essential fatty acid deficiencies?

A

Scaly dermatitis

Visual and neurological abnormalities

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6
Q

What are prostaglandins?

A

Eicosanoids with a short half life

Roles in inflammation and platelet homeostasis

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7
Q

How are prostaglandins made?

A

By cyclooxygenase using arachidonic acid

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8
Q

What are leucotrienes?

A

Eicosanoids
Longer half life
Roles in inflammation and neutrophil adhesion

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9
Q

How are leucotrienes made?

A

By lipooxygenase using arachidonic acid

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10
Q

What is the function of TAGs?

A

Storage of energy in adipose tissue

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11
Q

What is the function of DAGs?

A

Intracellular signaller

Mobilisation of calcium

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12
Q

Which sphingolipid contains H as its R group?

A

Ceramide

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13
Q

Which sphingolipid contains phosphocholine as its R group?

A

Sphingomyelin

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14
Q

What group of sphingolipids contain sugar?

A

Glycosphingolipids

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15
Q

Which glycosphingolipid contains galactose or glucose?

A

Cerebroside

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16
Q

Which glycosphingolipid contains a sugar with sialic acid?

A

Ganglioside

17
Q

What is characteristic of a steroid?

A

Fused ring system with a hydroxyl or keto group on carbon 3

18
Q

Name some major classes of steroids

A
Cholesterol
Bile acids
Progesterone and adrenocortical steroids
Androgens
Estrogens
19
Q

What are lipopolysaccharides?

A

Found in the outer membrane of gram negative bacteria
Endotoxins
Trigger strong immune response

20
Q

What are terpenes?

A

Any of a class of organic compounds composed of two or more units of hydrocarbons

21
Q

What does MCAD do?

A

Involved in mitochondrial fatty acid beta-oxidation

22
Q

What are the main clinical signs of an MCAD deficiency?

A

Intolerance to prolonged fasting
Hypoglycaemia
Impaired ketogenesis
Recurrent episodes of hypoglycaemic come

23
Q

How is an MCAD deficiency managed?

A

Avoid fasting

Glucose supplements