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Equine Medicine 2 > 3. Osteoarthritis > Flashcards

3. Osteoarthritis Flashcards

1
Q

Structure of normal joint

A
  • synovial membrane
  • synovial fluid
  • periarticular soft tissue
  • subchondral bone
  • articulate cartilage
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2
Q

Articulate cartilage

A
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3
Q

Chondrocytes

A

Synthesis of ECM! (Collagen, proteoglycans)
Degradation of ECM
-
-
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4
Q

Collagen in joint

A
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5
Q

Proteoglycans in articulate cartilage

A

If osteoarthritis -> decreased water binding capacity

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6
Q

Hyaluronan in articulate cartilage

A
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7
Q

Structure of joint capsule

A
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8
Q

Definition of osteoarthritis

A
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9
Q

Pathogenesis of osteoarthritis

A
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10
Q

Molecular pathogenesis of osteoarthritis

A
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11
Q

Normal joint vs joint with osteoarthritis

A
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12
Q

Pathogenesis

A
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13
Q

Abnormal forces on joint surface as cause of OA

A

Angular/flexor deformities

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14
Q

Disturbance in cartilage development as a cause of OA

A

…

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15
Q

Clinical signs of osteoarthritis

A
  • joint effusion increased
  • lameness
  • decreased range of motion
  • changes in synovial parameters (microscopically and lab parameters)
  • cartilage damage
  • new bone formation (osteophytes)
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16
Q

Lameness examination in diagnosis of OA

A
17
Q

Arthrocentesis — ?

A
18
Q

Diagnostic imaging in case of OA

A

Mainly radiography

19
Q

Radiographed changes in OA

A
20
Q

Synovial fluid analysis. What parameters are checked?

A

First microscopically (in OA viscosity will decrease)

  1. Leukocytes (cell/microliter)
  2. Neutrophil (%)
  3. TP (g/dl)
21
Q

Treatment of OA

A
22
Q

NSAIDs in OA

A
  • Phenylbutazone
    iv, po. SE: gastric ulceration, right dorsal colitis, papillary necrosis. **Cheap, can be used by owner (po)

flunixin-meglumine
iv, po. Analgesic effect mainly for soft tissues, postoperative care

…
..

23
Q

Corticosteroids in OA. General info

A
  • ia application
24
Q

Corticosteroids in OA. Drugs

A
25
Q

Hyaluronate sodium in OA

A
26
Q

PSGAG

A
27
Q

IRAP

A
28
Q

Biphosphonates ?

A
29
Q

Intraart icular polyacrylamide hydrogels

A
30
Q

Stem cells in OA

A
31
Q

Supplements in OA

A
32
Q

Surgical treatment of OA

A
33
Q

Chondroplasty

A
34
Q

Bone spavin

A

Equine Medicine 2 (9 decks)

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