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Integumentary > 3 - Responses Of The Skin To Injury > Flashcards

3 - Responses Of The Skin To Injury Flashcards

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1
Q

Skin patterns imply

A

The Pathogenesis and cause

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2
Q

Hyperkeratosis

A

Increased thickness of the stratum corneum

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3
Q

Hyperkeratosis can be due to

A

Non specific reaction to chronic stimuli

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4
Q

Is there a nucleus with othokeratotic

A

Lacks nuclei

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5
Q

Examples of causes of orthokeratotic

A

Seborrhea, icthyosis, vitamin A deficiency

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6
Q

What could cause parakeratosis

A

Zinc responsive dermatitis, superficial neuroleptic dermatitis

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7
Q

Epidermal hyperplasia

A

Increase thickness of the epidermis due to an increase number of cells

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8
Q

Epidermal hyperplasia occur where

A

Stratum spinosum - Acanthosis

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9
Q

Rete Pegs

A

Down growths of epidermis into the dermis

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10
Q

Where is rete peg normal

A

High friction - foot pads, gingiva

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11
Q

Where is another place you can find rete pegs

A

Chronic irritation

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12
Q

Epidermal dysplasia

A

Abnormal development of the epidermis

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13
Q

Disorganization of any of the layers of the epidermis

A

Epidermal dysplasia

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14
Q

Epidermal dysplasia is most often in what cells

A

Basal cells

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15
Q

Epidermal dysplasia is often what type of lesions

A

Pre neoplasticism

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16
Q

Epidermal atrophy

A

Decrease in number and size of the cells within the epidermis

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17
Q

Possible caues for epidermal atrophy

A

Hyperadrenocorticism, partial ischemia, severe malnutrition

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18
Q

What are some distinct Pathogenesis, but histologically identical

A

Dyskeratosis, apoptosis, necrosis

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19
Q

If dykeratosis/apoptosis/necrosis is confined to the basal layer

A

Discoid lupus/ muscocutaneous pyoderma

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20
Q

If dykeratosis/apoptosis/necrosis is multifola at all layers

A

Erythema multiforme

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21
Q

If dykeratosis/apoptosis/necrosis diffuse / full thickness

A

Toxic dermal necrolysis, thermal injury q

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22
Q

Edema

A

Fluid balance

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23
Q

Acantholysis

A

Loss of cell adhesion

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24
Q

Widening of intercellular spaces due to worsening edema lead to

A

Spongiosis

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25
Los of cells due to worsening edema leads to
Ballooning degeneration
26
Ballooning degeneration is what type of edema
Intracellular
27
Spongiosis is what type of edema
Intercellular edema
28
Loss of interest-cellular junctions resulting in separation of cells
Acantholysis
29
What do you think of when u see Acantholysis cells
Immune mediated process
30
Immune mediated process related to Acantholysis cells
Pemphigus
31
What are neutrophilic enzyme destruction that can h cause Acantholysis cells
Superficial bacterial folliculitis, and ring worms
32
Where can you look for Acantholysis cells
Vesicles and crusts
33
Which cell are r typically disassociated from others Acantholysis or Apoptotic
Acantholysis
34
What type of pemphigus is asooocaited with Superfifical
Pephigus folicaceous
35
Pemphigus folicaceous forms pustules where
Beneath the stratum corneum
36
Pemphigus vulgaris is characterized by
Suprabasilar cleft
37
Bulbous pemphigoid / thermal burns are characterized by
Completely separating from the dermis?
38
Exocytosis
Inflammatory cells walking through the epidermis
39
Crust
Form as pustules dry up or are pushed off by the hyperplastic epidermis
40
Hyperpigmentation is most commonly due to
Increased production of melanin by existing melanocytes
41
Hyperpigmentation can also occur due to proliferation of
Melanocytes
42
Lentigo
Black spots around the eyes
43
Pigmentary incontinence
Loss of melanin from pigmented cells in the basal layer
44
What is damaged in Pigmentary incontiene
Basal cells or melanocytes
45
In pigmentary incontience the pigment is phagocytes by
Macrophages in the Superfifical dermis
46
Dermal atrophy
Decrease in the quantity of collagen fibrils and fibroblast in teh dermis
47
Flame figures
Hyper - eosinophilic
48
Hyper - eosinphilic collagen degradation
Surrounded by eosinphils and major basic protein
49
Examples of eosinphilic degradation
Feline eosinphilic granulosum complex, canine eosinphilic granulomas, equine modular necrobiosis, habronemiasia, mast cell tumors
50
Mineralization
Calcinosis cutis - mineralization of the collagen
51
Calcinosis Cutis occurs in dogs with
Hyperadrenocortisicsm
52
Mineralization nodules
Calcinosis circumscribed
53
Hemidesmosomes attach where
To the basement membrane
54
Neutrophilic pustules
Bacterial and pemphigus
55
Eosinphilic pustules
Ectoparasites and pemphigus
56
Crust form as
Pustules dry up
57
2 examples of alterations in epidermal pigmentation
Hyperpigmentation and pigmentary incontinence
58
2 examples of hyperpigmentation caues
Chronic inflammatory disease and endocrine dermatoses
59
Pigmentary incontience is a feature what specific disease
Discoid Lupus and VKH
60
What can cause dermal atrophy
Hyperadrenocorticism
61
Responses of the dermis to injury
Alteration in growth, collagen degradation, dermal deposits, inflammation in the dermis
62
Mucin is in
Shar Pei or hypothyroidism
63
Perivascular dermatitis
Inflammatory cells are centered around teh blood vessel
64
Vasculitis
Inflammation is targeting the walls of the blood vessels
65
FIP and Sepsis can cause
Vasculitis
66
Interface dermatitis
Superficial dermal inflammation in the cells surrounding the dermo - epidermal junction
67
Interface dermatitis causes basal cells to be
Vacuolated and necrotic
68
Which pigmentation thing is seen with interface dermatitis
Pigmentary incontience
69
Lichenoid
Band beneath the epidermis
70
Nodular to diffuse dermatitis is usually
Infectious
71
Responses of the adnexa to injury
Alterations in growth and inflammation of the adnexa
72
2 alterations in growth of the adnexa
Atrophy and hypertrophic
73
Adnexa atrophy is indicative of
Endocrine or ischemia
74
Adnexa hypertrophy is indicative of
Chronic irritation
75
Inflammation of the adnexa can affected
Follicles and glands
76
Folliculitis overtime turn to
Furunculosis
77
Furunculosis
Inflammation associated with follicular rupture
78
Sebaceous amenities
Immune mediated reaction targeting teh sebaceous glands
79
Sebaceous adenitis is seen in
Akitas , standard poodles, vizlas
80
Pannuculus atrophy
Chronic negative energy balance
81
Panniculus hypertrophy
Obesity
82
Panniculitis

Integumentary (9 decks)

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