Drug Distribution

Question 1

Approximately how much of a 70kg individual is liquid?

Answer 1

60% of 70kg = 42L

Question 2

How much of the TBW is ECF?

Answer 2

1/3rd

Question 3

How much of the TBW is ICF?

Answer 3

2/3rd

Question 4

How much of the ECF is Interstitial Fluid?

Answer 4

3/4th

Question 5

How much of the ECF is Plasma?

Answer 5

1/4th

Question 6

What is the volume of distribution?

Answer 6

A proportionality between the amount of drug in the body and the corresponding plasma concentration

Question 7

What does the fraction of drug in the body within plasma equal?

Answer 7

Vp/Vd

Question 8

What does the fraction of drug outside plasma equal?

Answer 8

Vd-Vp/Vd

Question 9

What is the cardiac output under resting state?

Answer 9

The total blood flow in human which is 5000mL/min

Question 10

What is a protein bound drug usually?

Answer 10

Pharmacologically inactive
Has restricted distribution
Cannot be metabolized
Cannot be distributed

Question 11

What is an example of irreversible drug-protein binding?

Answer 11

Hepatotoxicity with high doses of acetaminophen

Question 12

What are 3 common binding proteins?

Answer 12

Albumin (60%)
Alpha1-acid glycoprotein
Lipoproteins

Question 13

What kind of drugs does albumin bind to?

Answer 13

Acidic

Question 14

What kind of drugs does alpha1-acid glycoprotein bind to?

Answer 14

Basic

Question 15

What kind of drugs do lipoproteins bind to?

Answer 15

Neutral

Question 16

What does drug accumulation depend on?

Answer 16

Blood flow

Tissue affinity