Cells and Organs of the Immune System Flashcards
How do neutrophils kill microbes?
They phagocytose microbes then kill them intracellularly
Do neutrophils initiate adaptive immunity?
No, because they do not present assigns to T cells
What are the 4 basic proteins within eosinophils?
Major basic protein
Eosinophil cationic protein
Eosinophilic derived neurotoxin
Eosinophil peroxidase
What are mast cells?
Essentially differentiated basophils in tissue
What kind of life span do macrophages have?
Long; months to years
What are macrophages called in the lung?
Alveolar macrophages
What are macrophages called in the liver?
Kupfer cells
What are macrophages called in the kidney?
Mesangial cells
What are macrophages called in the brain?
Microglial cells
What do monocytes not have?
Myeloperoxidase
alpha-defensins
What are T helper1 cells characterized by?
Aiding in cellular immunity
Secretion of IL-2 and IFN-gamma
What are T helper2 cells characterized by?
Aid B cells to produce certain classes of Ab’s
Secretion of IL-4, IL-5, IL-10
How does apoptotic signaling happen for Cytotoxic T Lymphocytes?
Via membrane bound molecules occurs via Fas on the target cell surface and Fas ligand on the CTL surface
What is the primary lymphoid organ?
Thymus
What stages do thymocytes go through to become T cells?
Positive selection
then Negative Selection
