1/17/15 Flashcards
What drugs are inhibitors of the CYP450 enzyme?
A Cute Gentleman "Cipped" Iced Grapefruit Juice Quickly And Kept Munching Soft Cinnamon Rolls Acute alcohol abuse Gemfibrozil Ciprofloxacin Isoniazid Grapefruit juice Quinidine Amiodarone Ketoconazole Macrolides Sulfonamides Cimetidine Ritonavir
What drugs are substrates for the CYP450 enzymes?
Always, always, always, always Think When Starting Others Anti-epileptics Anti-depressants Antipsychotics Anesthetics Theophylline Warfarin Statins Oral contraceptive pills
What is the mechanism of action of metoclopramide? What is it used for? What area of the gut does it act on?
D2 receptor antagonist used to increase GI motility due to diabetic or post surgical gastroparesis. Acts on the proximal GI tract but doesn’t increase motility in the colon.
What are the side effects of ondansetron?
headache, constipation and prolonged QT interval
What lipid lowering drug increases the risk of cholesterol gallstones?
fibrates (gemfibrozil, fenofibrate)
What are the physical symptoms of hypercalcemia?
fatigue, muscle weakness, depressed mood, constipation
Why would an alcohol abuser being treated for a C. Difficile infection develop nausea, vomiting, palpitations, flushing and a headache?
C. diff is treated with metronidizole which inhibits aldehyde dehydrogenase, causing a build up of acetylaldehyde which manifest as nausea, vomiting, palpitations, flushing and headache
Which antibiotic class has the side effect of cholestatic hepatitis?
macrolides like erythromycin and clarithromycin
What drug is used to treat Wilson’s disease?
penicillamine
Why should you never give a child with diarrhea from a suspected infection of a enteroinvasive organism (dysentery) an antidiarrheal medication?
because of the risk of toxic megacolon (not passing stool, visibly distended abdomen, absent bowel signs and diffuse abdominal tenderness)
What drug used to treat GERD impairs the oral absorption of ciprofloxacin?
calcium carbonate or any divalent cation
