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Ther 201 3rd Exam > Antibacterials 6 > Flashcards

Antibacterials 6 Flashcards

0
Q

50S inhibitors

A

Chloramphenicol
Macrolides
Clindamycin

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1
Q

100 % oral bioavailability, 7% renally excreted

A

Chloramphenicol

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2
Q

Binds reversibly to 50s subunit, inhibits peptide bond formation, bacteriostatic broad spectrum, active against Rickettsiae not chlamydiae

A

Chloramphenicol

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3
Q

Cloramphenicol inactivation

A

Glucuronidation

Reduction to aryl amines

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4
Q

Oral formulation for bacterial meningitis for penicillin sensitive patients

A

Chloramphenicol

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5
Q

Topical for eye infection, typhus, Rocky Mountain spotted fever

A

Chloramphenicol

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6
Q

Adverse effect

Gray baby syndrome

A

Chloramphenicol

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7
Q

50S inhibitor that crosses the placenta and is present in breastmilk and CSF

A

Chloramphenicol

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8
Q

Macrocyclic lactone ring

A

Macrolides

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9
Q

Romycins

A

Macrolides

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10
Q

Blocks polypeptide exit tunnel

A

Erythromycin, macrolides

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11
Q

Special formulation of macrolides?

A

Enteric coating bec destroyed by stomach acid

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12
Q

50s inhibitor, lost in feces and bile

A

Erythromycin

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13
Q

Drug of choice in corynebacterial infections

Diptheria, sepsis, erythrasma

A

Erythromycin

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14
Q

Macrolide more active against M avium complex

A

Clarithromycin

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15
Q

Macrolide active against M avium, T gondii, H inf, Chlamydia, but less active against strep, staph

A

Azithromycin

16
Q

Macrolide that does not inhibit cyp450

A

Azithromycin

Ther 201 3rd Exam (16 decks)

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